Tenofovir Clinical Trial

[luckyman316]

Currently on a clinical trial (TAF vs TDF - double blinded study). Started meds 3 days ago, didn't notice any side effects until later yesterday. I can only describe it as my feet and legs feeling cold. Did some research and it's suggested lactic acidosis. Should I be concerned this early on about this? I'm not sure if it's a side effect of the drug or just the cold weather doing it right now (I also sit under an air vent all day at work). At what point should I be worried?

[luckyman316]

Whatever this was a symptom of, seems to have subsided. I believe it was due to the cold air that day.  I have had episodes of "dizziness" but I believe this was occurring prior to meds, so I don't think the meds are causing this. I'm on day 5 and don't feel a change... nor do I notice any issues so far.

[luckyman316]

That is correct... however, it's a double blinded study so I don't know if I have TAF or TDF right now (neither does my doctor). I have a 2 out of 3 chance that it is indeed TAF.

[Seattledude]

Trial is to see if TAF is as effective as TDF, also to check effects on kidneys. TAF is more targeted so much less drug should have same effect w/ no sides or kidney issues

[makeadifferencenow]

If your doctor says  its ok then I would assume its ok


But here's the link for Viread site side effects etc

http://www.viread.com/en/

Sorry I can't be of much help.

Whats the purpose of the trial may ask please?

[luckyman316]

Just talked to my doctor and he said it was not the drug causing this symptom and Lactic Acidosis from these drugs does not occur. He said it is a class warning but is not really relevant for these medications. Hmmm

Hoping it's just the darn cold air we are getting. I usually tolerate cold pretty well too!