Aa
Tenofovir Latest Trial - 3% lost HsAg
Look like Tenofovir is more impressive the Balaclude.....3% is better than none!
If I could add to the 3%, you folks will be the first to know ;) But maybe it's not the TDF, rather well-done pizza burgers since I've been eating these things like crazy. Either way, I would let yous know.
I think more study is needed on the drug but it sounds promising.
A big red flag in the study I referenced was when I saw patients that used LAM only also achieved 8% sAg loss. I don’t know how to explain that. Did 8% of all those patients just spontaneously clear? I doubt it. I won’t put much stock in the study I found.
I would however like to see the data that Ann8 found about 3% loss. Maybe it is part of a much larger study.
Anything that gives us hope.
A big red flag in the study I referenced was when I saw patients that used LAM only also achieved 8% sAg loss. I don’t know how to explain that. Did 8% of all those patients just spontaneously clear? I doubt it. I won’t put much stock in the study I found.
I would however like to see the data that Ann8 found about 3% loss. Maybe it is part of a much larger study.
Anything that gives us hope.
Thank you for the source.
I would not put a lot of weight on this study:
1. a small study, as authors recognized;
2. study stopped at week 48, no follow up.
What do you think?
I would not put a lot of weight on this study:
1. a small study, as authors recognized;
2. study stopped at week 48, no follow up.
What do you think?
Well, I just found the following study of HBV/HIV co-infected patients using LAM and Tenofovir:
Well, I just found the following study of HBV/HIV co-infected patients using LAM and Tenofovir:
http://clinicaloptions.com/HIV/Conference%20Coverage/Sydney%202007/Tracks/Complications/Capsules/TUAB205.aspx
You may need to register to see it. If so…it is free.
The weird thing is, this study also shows an 8% HBsAg loss when using LAM alone. So now I’m thoroughly confused about this figure.
You may need to register to see it. If so…it is free.
The weird thing is, this study also shows an 8% HBsAg loss when using LAM alone. So now I’m thoroughly confused about this figure.
Well, I just found the following study of HBV/HIV co-infected patients using LAM and Tenofovir:
http://clinicaloptions.com/HIV/Conference%20Coverage/Sydney%202007/Tracks/Complications/Capsules/TUAB205.aspx
You may need to register to see it. If so…it is free.
The weird thing is, this study also shows an 8% HBsAg loss when using LAM alone. So now I’m thoroughly confused about this figure.
You may need to register to see it. If so…it is free.
The weird thing is, this study also shows an 8% HBsAg loss when using LAM alone. So now I’m thoroughly confused about this figure.
I know my interest was peaked when I read the following in the Unofficial Research Thread regarding 8% HBsAg loss:
>>>>>A recent study of 69 patients, who had never been treated with an antiviral before, showed consistent suppression of HBV DNA and no signs of viral resistance after five years of tenofovir treatment. HBeAg seroconversion was documented in 36 percent of the patients and HBsAg loss in 8 percent after two to three years. Some physicians are using this drug “off label,” even though it has not yet been approved by FDA, to treat hepatitis B patients who have developed resistance to lamivudine and adefovir.<<<<<
When is this drug expected to be approved for HBV treatment? Most of the info I find about it, deals with HIV
>>>>>A recent study of 69 patients, who had never been treated with an antiviral before, showed consistent suppression of HBV DNA and no signs of viral resistance after five years of tenofovir treatment. HBeAg seroconversion was documented in 36 percent of the patients and HBsAg loss in 8 percent after two to three years. Some physicians are using this drug “off label,” even though it has not yet been approved by FDA, to treat hepatitis B patients who have developed resistance to lamivudine and adefovir.<<<<<
When is this drug expected to be approved for HBV treatment? Most of the info I find about it, deals with HIV
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