Tenofovir vs. Entecavir

[TaG_99]

cheers to all those fighting with B Hep and I wish you all fast recovery!

My story in short:

Started entecavir
Oct 2013                 DNA=11,200,000 HbsAg=11,200
Feb 2015                 DNA< 6               HbsAg=  1,025
Jun 2015                 DNA< 6               HbsAg=  7,500

Now my doctor says that actually multiplication of virus should've been stopped due to absence of viral DNA material.
But as I see, HbsAg results reluctantly deny this. doctor offered to try Tenofovir for at least three months...

My liver functions are all OK (ALT, AST, GGT, creatinine, billirubin), but my Elastyography as is awful over 21... (I guess because I had for many years B Hep, but did not know about it).

Question to community: Any ides how to go ahead further?

Thanks in advance

[stef2011]

with antioxidants, organic fresh foods with no chemical, liver compensated, good albumin and platelets, low bmi, it is possible to regress cirrhosis

the point of no return is not set for sure, micronodular cirrhosis is about the area of no return, decompensated also

[stef2011]

11.5kpa starts the risk
12.5-13kpa very probable cirrhosis
over 18kpa is very high and cirrhosis decompensation may happen on higher values

[needadvicewithhep]

What reading is the MAX in terms of KPA. before its not considered cirrhosis?

[needadvicewithhep]

What reading is the MAX in terms of KPA. before its not considered cirrhosis?

[Jatashankar]

Peginterferon are weekly injections used to treat hep b.

[Jatashankar]

Recheck ur fibroscan regularly after 3-6months and when it comes to a considerable lower value ask ur doc to add peginterferon injections. Right now u aren't fit for peg.

[stef2011]

is you have 21kpa this is advanced cirrhosis and you must take antiviral indefinitely even after clearing hbsag you must keep antiviral for at least 1 year

as to best drug tenofovir is superior to entecavir, if you want to change it combo etv+tdf one month and then discontinue etv

[TaG_99]

Sorry,

what is "peg" for?

and

yes, my Fibroscan values are 21 for over 3 years now...

[Jatashankar]

Ur hbsag raised from 1025 to 7500.. That's not a good response and u should ve added peg in feb like many members talk here.

[StephenCastlecrag]

I am not a doctor. I just like to make a few comments.
It is very good that you have responded well to Entecavir and I think you should keep on taking the medication.
As for your HBsAg, I would like to see the unit for your results. If they were in iu/ml and were carried out at the same lab, I would suggest a re-test of your serum HBsAg. Oral drugs like Entecavir and Tenofovir, can only inhibit the replication of the virus, and as your doctor said, Entecavir has been effective and you now have a very low level of replicated HBV virus in your blood. However, HBsAg is produced separately from the cccDNA in infected liver cells and released into the blood in great quantity in the form of SVP (sub viral particles). These SVP are not infectious as they contain no viral DNA.
When you say your Elastypgraphy is over 21, do you mean your Fibroscan score is over 21 kpa?
You may like to repeat your Fibroscan, hopefully you should see an improvement that should continue with a sustained reponse to Enetecavir.