Data to be Presented Today at The Liver Meeting® 2012 in Boston
BOSTON, Nov. 10, 2012 – GlobeImmune, Inc. today announced that GI-13020, an investigational therapeutic vaccine designed using the company’s proprietary Tarmogen® product platform for the treatment of chronic hepatitis B virus (HBV) infection, demonstrated immunogenicity in two preclinical studies. GI-13020, which is being developed in collaboration with Gilead Sciences, Inc., was found to activate antigen-specific CD4 and CD8 T cells, including those that respond to the HBV X, S and Core antigens, which are critical for the development of hepatitis B disease. These data will be presented today at The Liver Meeting 2012 in Boston.
A poster by Guo et al. will include data demonstrating antigen-specific T cell responses generated in mice immunized with GI-13020. In addition, the data will show that GI-13020 significantly protected mice from tumors engineered to express HBV antigens. In a second poster by Kemmler et al., Tarmogens elicited HBV-specific T cell responses ex vivo in samples collected from healthy individuals and donors with chronic HBV. Further analyses showed that the Tarmogens were able to elicit functional immune responses in a clinically relevant model.
“Chronic HBV infection, which is characterized by inadequate and dysfunctional T cell responses against HBV antigens, can be effectively suppressed with long term antiviral therapy. However, there is a significant opportunity to improve permanent cure rates,” said David Apelian, M.D., Ph.D., Senior Vice President, Research & Development, and Chief Medical Officer of GlobeImmune. “We believe that administration of GI-13020 in patients whose disease is under virologic control with a direct acting antiviral agent may have the potential to increase hepatitis B surface antigen seroconversion rates, thus potentially allowing discontinuation of antiviral treatment.”
Link : http://www.globeimmune.com/archived-news/2012-press-releases/gi-13020-tarmogen-for-the-treatment-of-chronic-hepatitis-b-generates-antigen-specific-t-cell-responses-in-key-preclinical-studies/
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