Timeline for Arrowhead Chronic HBV Franchise (update 23 July 2013)
HBV, next HCV. The time for a cure of chronic HBV has come. This page provides a quick overview over the progress of one of the most exciting treatment approaches towards this goal, the HBV RNAi franchise by Arrowhead Research.
23 July, 2013: Start of dosing in Australia phase I single-dose healthy volunteer safety trial; company guides for results in Q4 2013 and phase IIa Hong Kong in-patient study start early 2014.
28 May, 2013: Company files for phase I IND with Australian authorities
25 March, 2013: ~90% reduction in HBsAg in chronically infected chimpanzee with very viraemia in 2-dose experiment
28 February, 2013: US patent granted for protease-sensitive DPC (à important for subcutaneous follow-up to ARC520)
26 February, 2013: multi-log knockdowns of all HBV markers, incl. critical HBsAg, in various rodent models
27 November, 2012: publication of DPC co-injection strategy on which ARC520 is based
29 October, 2012: impressive liver gene knockdown results in first presentation of subcutaneous DPC formulation (à ARC520 follow-up)
7 August, 2007: publication on prototype RNAi DPC delivery system
they are approaching it the way, they can maximize their share of market and fame as bonus for next 20 years in pharma industry. they are trying to push their competitor to back bench so they can be the leader and eat whole market alone.
i can guess who ever come with a patented cure even functional, you can think 300 million people even if 50 million is going to buy treatment ,you can imagine huge huge profit. definitely much higher than nucs as now generic nucs are there and people are not preferring nucs. keep in the mind hvb treatment was never cheap and neither it would be.
surely the curer will get place in the world top 5 profit pharma. surely
that is why they are using these strategy to push their competitor behind. it is not good for us as they want dis-appointment in other pharma companies and monopoly in market.
There are worst things than present treatment of hep B. We have a chance with sequential therapy. At least there is control. People claim their products cure everything. Then when it does not work they blame on every thing else, including the patient wearing the wrong colour socks. So they need to prove it works effectively in thousands of people. Drugs can also do irreversible damage to other parts of our bodies. Some side effects only become apparent after it hits the market.
so we must consider available treatment and our own new therapies like vit d, vit c push for our own interferon generation etc. as stef pushes.
pharma wants us to be dependent on them for cure. so what we need to do is put a kick on their axxxses and this is the solution for thier frod claims.
FDA must pose some stop on their frods and exaggereted claims and we must be reluctant to promote their claims. though it is difficult to not beleive even we know their claims are frod because of this desease.
All this is true. But there is really very little alternative to the big pharma monopoly and how they do things. Go about clinical trials and so on. How they train doctors etc. This so called standard treatment really only adds to the cost of health care. And produces very little results in terms of disease cures. Despite that the technology and know how is there.
You have to understand if people enter medical schools on grant money from big pharma grants they will get trained in a way to only think in the parameters set up by drug companies when it comes to approaching treatment.
That is why most US trained doctors dont do their own thinking. They see you you have CHB they look in the book what is approved and prescribe it. Which is 99% of the time will be nucs. And that is it. Past Entecavir or Tenifovir the guy has no info. No info on what is being developed. So this means these guys have zero interest in their profession.
No matter how nicely you will try to reason with the doctor about better treatment strategies that are proven to work better. You will be told NO.
And where to find true research clinics that do gene therapy. Immune therapy. All the cutting edge stuff most of us have no idea.
That is why we have to wait till 2020 to see something that works today. Because by that time public opinion on nucs and general interest to them will be gone. as well as all the profits will be made exhausted also. Which is why they call it a pipeline :( And then big pharma that controls this game will wiggle the magic wand and say Oh look what we got for you folks after years of research.
Anyway all that is Arrowhead is doing is great. But 2020 is ridiculous time line. Clinical trials from concept to market should not take more then a year or 2 maximum.
as soon as they establish that the medicine or therapy is safely tolerated in phase 1. Run a massive phase 2 and 3 treatment trials. up to 500 people say. And boom they have all the real data right away. If it works or not.
But instead finance people of these companies decide to milk their investors on slow development funds. Research institutions play along to get a piece oft the action. And we get where we get today. Extremely long medical trials. in which they really anyway cant establish is the drug safe for a long term use or not. This data they get from treating physicians btw over years time.
I say this guys. If nobody representing these drug companies that are developing these drugs comes to these forums to talk to us. Even though they monitor all we say here. Then I say there is very little regard towards us patients.
yes guys.....now the time has come to raise a general awareness about the dust and dirt in the traditional medical system and the way so called fundamental institutes are doing research.
USA people must raise their voice in general against the medical system so this medical service field would become an issue in the next election.this traditional medical system must be changed and it will automatically changed in the rest world if leader usa will be ready to change.
now this is a time to hit the root of the problem it is not only about hep b ,it is about most of the deseases, pharmas are only making money even they know cures and fundamental research institute are also deeply deeply involved with them in passing time with ridiculous, useless and cumbersome trials.
fundamental institutes are neither doing fundamental research nor supporting any fundamental non-commercial idea like vit d.
if nasa's grant may be stopped why not stop the government grants of dull medical institutes..they must be clearly told either they should give our people cure or ready to get closed no need of them.better they are closed if not doing any good instead bad.
Potential Breakthrough Cure for Chronic Hepatitis B Enters Clinical Development.
Dirk Haussecker said... If all goes well...intravenous form launched in 2016/7, subcutaneous form 2020/22, tablet...more uncertain, but there are oral delivery strategies that should be possible for DPC tech.
June 30, 2013 at 1:09 AM
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