I would like to start a topic where mothers with HBV can share experiences, knowledge and personal stories with regard to mother and child's hep B status, pregnancy, etc. I trust for each and every mother with HBV, the biggest wish is that our own little angel is not infected with the virus. Prevention is possible if mother can access to good advice at the right time.
I hope this sharing with help HBV mothers and HBV mothers to be. Sometimes, being able to tell other your stories will be of great help emotionally, too.
Safety of Discontinuation of Antiviral Agent during Pregnancy in Women Infected with Hepatitis B Virus
Hee Yeon Kim, Jong Young Choi, Chang Wook Kim, Jeong Won Jang, Chung-Hwa Park, Si Hyun Bae, Seung Kew Yoon, Ho Jong Chun, Chang Don Lee, Young Sok Lee
The Catholic University of Korea, Seoul, Republic of Korea
Background: Women who are taking antiviral agents and become pregnant have several options that include, continuing therapy, ceasing drugs, or switching to safer drugs. However, there are limited data on the outcome in pregnant women after withdrawal of antiviral agents.
Objectives: We aimed to investigate the outcome of stopping antiviral agents in pregnant women with chronic hepatitis B virus (HBV) infection.
Study design: In this single-center, retrospective cohort study, 12 pregnant patients who had received antiviral therapy for HBV and cease drugs after awareness of pregnancy between 2002 and 2010 were enrolled. We retrospectively studied virologic and biochemical flares during pregnancy and postpartum period.
Results: Median age at pregnancy was 30.5 (range, 24─35) years, median duration of antiviral drug before pregnancy was 15.3 (range, 3.0─131.3) months, and median HBV DNA at withdrawal of therapy was 4.8 (range, 1.7─8.0) log10 copies/mL. Eight out of 12 patients (66.7%) had a viral rebound after stopping antiviral drugs during pregnancy. Severe hepatitis flares, defined as a 5-fold increase in serum alanine aminotransferase (ALT), were observed in six patients (50%) during pregnancy. However, most patients spontaneously recovered without an event of hepatic decompensation. High pretreatment ALT was associated with severe hepatitis flares after cessation of therapy during pregnancy. Five patients with at least 1-year treatment before pregnancy maintained low hepatitis activity after delivery.
Conclusions: Pregnant women with high pretreatment ALT or those treated less than one year before pregnancy have high risk of severe hepatitis flares after cessation of antiviral agents.
Dr. Ho Jong Chun, The Catholic University of Korea , Seoul , Republic of Korea
Assigned in sessions:
07.06.2013, 08:30-17:30, PT-4, HEP B Clinical, Exhibition Hall
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