Could you please make it clear for me and sure many forum users will find your reply usefull as before travelling :
If syringe with Interferon alpha will be kept for 24 hours in room temperature and then put back in refrigerator, what will happen with interferon? Will it be out of order? I called Hot line in US and they say should be no problem but as they say this only applies to Pegasys which is sold within US while I called hot line in my country and they say only +2-8C storage. Who is right? I understand pegasys is same everywhere.
I am going to travel next week and have to take Peg with me and I am not sure I will be able to kept it in 2-8C all the way.
I am pretty sure that the inherent stability of the 40kd pegylated interferon preparations is very similar for all producers, whatever the brand name might be.
There will be some acceleration of spontaneous decay at room temperature, the exact degree of which can only be dermined experimentally. My guess is that maybe 10% activity is lost after 24 hour at room temp.
But at travel you can use a cold pack and wrap it together with the syringes in an insulating towel, placed inside of that towel in an aluminum foil around the cold pack, then place it back in a refrigerator quickly after arriving at your destination.
Had to travel with pegasys recently and here is what I have done. I had two syringe of pegasys wrapped in insulating towel, then two gel packs on each side ( The blue eutectic gel is for use with products between +2/+8°C http://www.sofrigam.com/snowgam-gel-packs). Then I wrapped pegasys, insulating towel and gel packs sandwich with aluminium foil and put in the cooler box. I also put electronic termometer between the syringes. In total I had about 18 hours travelling time. When I got to the hotel I checked the temperature and it was 0,5C after such a long flight. I assume that during the flight the temperature inside the cooler box was surely below 0C maybe -5C or even more. Will such low temperature destroy interferon activity. I am going to travel soon and need to take some peg with me again, so now I am experimentally figuring out how much gel packs I need to maintain right temperature in cool box. Thanks
Copyright 1994-2016 MedHelp International. All rights reserved.
MedHelp is a division of Aptus Health.
This site complies with the HONcode standard for trustworthy health information.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.