Want to share treatment results. My son has been on TDF since 6 months ago with the following results:
Baseline (before taking Tdf):
SGOT 47 (range for normal: 5 - 34)
SGPT 102 (range for normal: 4-36)
HBV DNA 2.43 X 10^8
HBSag Quantitative: 43,205.18 IU/ML
Result after 3 months:
HBV DNA 3.19 X 10^5
HBSag Quantitative: 11,570.50 IU/ML
Anti HBe non reactive
Result after 4 months
HBsAG Quantitative: 6,029.41 IU/ML
Result after 6 months
HBsAG Quantitative: 3,482 IU/ML
HBV DNA 5.7 X 10^3
I notice that in the beginning of the treatment HBsAG drop very fast from about 43,000 to around 11,000 in 3 months but in the following 3 months it reduces slowly from 11,000 to 3,482. I do hope it will continue declining.
What a bit worry me is that his monocyte count, eosinophil and basophil are a bit elevated. Other blood counts are within normal range, including leucocyte and creatinine.
Will appreciate your views on the slowing decline on HBsAG (whether it will continue to decline) and on the elevated monocyte, eosinophil and basophil.
very encouraging hbsag trend. Most will not experience such decline even with interferon. As for slowing decrease trend - as hbsag gets to lower numbers the decline rates lowers as well. You can clear thousands of hbsag iu/ml in a month or even a week but when it gets very low it can take months to clear some remaining units. Good Luck !!! I hope your son clears hbs with TNF.
i was checking response to tdf and hbsag decline, the decline experienced by your son is quite a lot by 6 months only so it is not reflected by the hbvdna decline but by some immune activation thanks to hbvdna decline.
hopfully it will continue, keep checking hbsag and if available ip10 too (ip-10 over 350pg/ml reflects activation of endogenous interferon).
according to hbsag response and hbeag seroconversion and ip-10 levels peginterferon add on might be considered before 3 years to fasten the hbsag decline/loss
IP-10 test is available at synlabs in europe
also check vit d levels and if low supplement (at least 40-50ng/ml of vitd25oh in serum)
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