Treatment with Pegasys

[aer479]

Is there any person experienced with Pegasys? my docor recommended it with me weekly injection. Please suggest if you have any knowledge about this medicine.

[stef2011]

not to clear hbv for now but a combo of etv+tnf can keep hbvdna und almost in 99% patients.hbvdna und will block liver damage but not the infection

[aer479]

If interferon fail, is there any other medicine to think of? thanks.

[stef2011]

there are interferon efficacy rules mainly based on hbsag and much less based on hbvdna
you need both but if you dont get 0.5log decrease of hbsag by 24 weeks interferon is a failure despite hbvdna

[PinoyHBVDNA]

No

HBSAG quantity quantifies the amount of HBSAG antigen in your blood, HBSAG on the other hand only says YES/ NO.

[aer479]

Is hbsg quantity and HBsAg is the same thing?

[stef2011]

hbvdna on interferon is useless, you have to check hbsg quantity

[aer479]

Abbott Real Time PCR (Plasma) is used to measured , Is it the same as abbott architect as you mentioned? My baseline viral load result is 59,261,846
IU/mL and after 13 weeks of therapy with infereron alpha the test shows 53,302,442 IU/mL, the mathematic differrent is 5,959,404 IU, however if say by Log it does not change much, anyway you might know than me. Please also comment whether it is on track of off track.

[LJ8785]

pls explain this result

                   CUT-OFF VALUES    PATIENT VALUES
HBsAG                      1.0                 4095                    REACTIVE
Anti-HBS                    10.0             less than 2.0          NON-REACTIVE
Anti-HBc-IgM              1.0                 0.078                   NON-REACTIVE
Anti-HBC-IGG             1.0                 0.016                   REACTIVE
HBeAG                      1.0                0.079                    NON-REACTIVE
Anti-Hbe                     1.0                0.003                   REACTIVE


God Bless us....

[stef2011]

interferon efficacy can be measured by hbsag quantitative only, you have to check your hbsag by abbott architect before therapy and at 24 weeks if there is no change interferon can be stopped because not working.

all other tests  are not useful to measure interferon efficacy, keep inmind that interferon is the only one able to clear hbv in a few, and that simvastatin, vitamin d3 and alinia increase chances of response

[aer479]

that why my virus has not changed when using Pegaysys interferon alpha, I do wonder about my doctor, why she recommended it to me since it give little chance to change the virus.. after 13 week of therapy with interferon alpha there is nothing change.. should I continue using it or should stop? Please help me.

[stef2011]

I wonder why only " HBV e antigen positive" patient? why not e antigen negative?

i think they have little money for trials and want to see the improvment compared to normal interferon and hbeag positive has better results than hbeag neg

it should be approved fast since it is just another type of interferon, not a complitely new drug

[ono8ono]

there is a clinical trial going on in my city :

Pegylated Interferon Lambda (BMS-914143) Monotherapy in Interferon-Naive Patients With Chronic Hepatitis B Virus Infection Who Are HBeAg-positive

"Inclusion Criteria: - Infection with the hepatitis B virus (HBV) and positive for the hepatitis B e antigen - Between the ages of 18 and 70 - Have not been previously treated with an interferon Exclusion Criteria: - Not infected with the hepatitis C virus (HCV), hepatitis D virus (HDV) or human immunodeficiency virus (HIV) - Do not have a serious liver, psychiatric, blood, thyroid, lung, heart or eye disease"

I wonder why only " HBV e antigen positive" patient? why not e antigen negative?

[stef2011]

i was scheduled to start interferon+alinia+entecavir this month but together with researchers we chose to avoid interferon for now since:

interferon lambda will be available soon, interferon has very little chances of hbv eradication when hbsag is higher than 1500iu/ml

[stef2011]

two members cleared hbv, it is necessary to check hbsag quantity by abbott architect to know if the treatment works but some countires dont have it so check for it so you can avoid sides effects, waste of money and see if you are eradicating infection, hbvdna is not enough

cmbo with tenofovir or entecavir increase the eradication from just 10% to more than 30% in two years of continuous therapy and also the use of alinia boost response to an higher percentage

alinia is a free of sides antidiarrea drug used on babies even 1yo, it boosts interferon response and have been used on hcv and hbv off label, it is an orphan drug so there will never be authorization for it on hbv or hcv, no money for big trials, so only off label is possible or buying it online.there are generics in many countries in this forum we are using nizonide500 from lupin

if you start one of these combos please report improvments to our community.only very updated liver specialists or researchers know what i posted, normal liver specialists who dont update their knowledge on hbv are complitely unaware of these news and just use interferon like 5 years ago

keep in mind that monotherapy is very weak and doesn t carry benefits, interferon monotherapy has also been linked to hbsag mutations and occult hbv which are much more dangerous than simple hbv infection, hbsag mutants are detected only by abbott architect, roches hbsag quant or siemens hbsag assay all other tests give it as negative giving the false illusion hbv has been eradicated while it is not.
hbsab antibody is usless on hbsag mutants

if this therapy is ot urgent due to liver damage it is better to wait for interferon lambda which is more potent without sides like interferon alpha