Treg/Th17 cells balance in the development of acute and chronic hbv

[stef2011]

http://archive.mail-list.com/hbv_research/message/20120513.234914.8acab6c1.en.html

CONCLUSIONS:

Th17 cells are involved in acute and chronic HBV infection, especially
in AHB and ACHBLF. CHB and ACHBLF patients manifested obvious Treg/Th17
ratio imbalance, which might be linked to disease progression and the
continuous HBV infection.

[stef2011]

such easily intf induction might be also the result of concomintant macrophages activation by gcmaf:

suppository, intf induction and low fever even at 12,5mg every other day but no effect on hbsag within 2 weeks of use like for gs9620 in the woodchuck

oral, no fever even at 25mg everyday but irritability, pains and very low fever like 37.2° if taking 2 caps 12.5mg at different time during the day instead of 1cap 25mg all at once

[stef2011]

i guess you saw the main thread already

http://www.medhelp.org/posts/Hepatitis-B/gilead-trl7-agonist-and-others-already-marketed/show/1685432

oral or suppository are the best routes, as you can see in the thread suppository had cytokine storm and intf at 2 caps a day 25mg total while oral route never had so much intf and fever but low fever, muscles pain and irritability are induced by oral route too so intf production is henanced anyway

what would you suggest to improve oral absorption to the liver?
i am using gastro resistant caps (made for garlic) and coating caps with a lot of vaseline

[stefen143]

it's one of the structures that i have investigated in the past 2 years. potential for iv or oral route. somehow it has similar structure activity relationship with the one your endorsing that is nitazoxanide. if you studied organic chemistry you might find some homologues and determine specific structures which has a potent activity against the HBV replication process.

[stef2011]

imiquimod lowers t-regs and th17, if we can get it to reach liver........