no use it anyway the fact it doesn t respond well is the same as genotype D and little less C, just a chart from the most responders to the less ones
@stef2011. Genotype E does not respond well to interferon ,? Please what do you advice me to do now. 1) should I stop interferon and start tenofovir ? My viral load is 7998IU/l fibroscan f1/f2
http://www.vitamindwiki.com/No,+do+not+need+9,000+IU+of+vitamin+D+to+get+most+people+above+20+ng+%E2%80%93+Oct+2014
Original error paper - Oct 2014
A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D
Nutrients. Oct 2014; 6(10): 4472–4475.Published online Oct 20, 2014. doi: 10.3390/nu6104472
Paul J. Veugelers and John Paul Ekwaru
http://www.vitamindwiki.com/Vitamin+D+Recommendations+around+the+world+-+IU+and+ng
and this is not for chronic hbv carriers or damaged livers, this is mainly for healthy
just browse medhelp hbv community from 2010 there are all study links and all members supplementation and results especially because the vit d levels are correlated to immune response and inverse to hbvdna
when the liver is very damaged like cirrhosis the liver cannot produce vit d anymore, in these cases the doses like 300.000-500.000iu are also not sufficient because they increase vitd25oh of 1-5ng/ml only.......so there is no max dose, everyone must start with 10.000iu which is normal dose and half what we make with the sun per day which is around 20.000iu and then see if the liver can make it
the vit d we take by supplements need many transformations t other substances that go into tissues and our organs are damaged, receptors modified by pathogens, so for those with no damage 5000 to 10.000iu are sufficient fr those with damage the dose needs to be adjusted by monitoring levels of 25oh/intact pth
there is also recovery of course, for example before pegintf i needed 150.000iu daily today 20.000iu daily
another very important note:
for doses over 10.000iu daily an exert doctor on vitamin d (rare to find) is needed for monitoring of calcium and so on and also no dairies diet, 2.5L of water dily.for doses less than 10.000iu nothing is required
genotype E is from africa/nigeria, it responds bad to peg unfortunately
with 1000iu you better drink water it could make more to your vit d pathways.....
we already taking vit d from years here the minimum to start is 10.000iu then after 3-4 months you check vitd25oh and intact pth in particular and see if you need more or little less
look for brands like healthy origins 10.000iu, nowfoods 10.000iu, biotech 5000iu.we already checked brands for quality many brands have bad oils with vit d3, oliv oil is the best because other oils can become rancid and give problems/sides (rancid oils are very bad oxidaizers).biotech is very good because it is the only one with water soluble powder so very absorbable.maxhealth labs makes it liposomal but it costs too much
purity pride, you mean puritan.com?they have all types, 10.000iu is the cheapest but oils are not oliv oil
you have also to look for doses for chronic illnesses and hbv not doses for healthy persons, viruses hijack vit d pathways and your doses cannot be the one i mentions you have to test vitd25oh and intact pth to know what you need and not vitd25oh
all studies were wrong on purpose, the minimum doses are:
pregnancy 6000iu
adults 7000-10.000iu
deficiency less than 10ng/ml need 1 million iu single dose according to guidelines
avoid anything from US institutions, corrupt and all doses wrong, refer to european or asian studies less corrupt
I'm not stef2011 but just chiming in -
I am also on a 1000 IU tablet for D3. I take it once in morning and once in the evening. I also take a normal multivitamin that has 700 IU D3 as a part of it.
From what I've read 1000 IU *sounds* like a lot but it's really a low dose. You and I could probably take higher doses safely if we wanted to.
@stef2011 what is intact pth? And the vit D3 capsule that I found here is 1000 IU from purity pride . What is your advise now
@stef2011 thanks i didn't do genotype test but most carrier here are genotype E I will be posting my result every 12 weeks to monitor the response. There is still a long way to go for chronic hep b carrier here . I show my fibroscan result to one doctor today he told me that there is nothing like fibroscan in medical line that the only test to access liver damage is through liver biopsy . He even told me I don't need treatment with 7998IU/ml viral load . That how they are killing people with wrong approach
Another stupid doctor you should base response to 24 weeks hbsag and hbvdna.12weeks if you know genotype, hbsag and hbvdna, i guess genotype has not been checked.....
i dont remember if there are stopping rules on hbvdna, not that useful to understand peg response
@sorte it is not the same doctor . This is a new doctor my question weather I can still use pegylated interferon the second time with HBV DNA OF 7998 IU/ml
Is it not too early to stop peginf if hbv dna detectable in week 12 ? I don't remember anything like this in any guidelines but I may be wrong.
Is it the same "doctor" who stopped peginf after 24 weeks because you HBe seroconverted ?
You can take one single 50.000iu dose and then 10.000iu daily, recheck vitd25oh and intact pth by 4 weeks, look at intact pth to be lowest norm more than vitd25oh