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VIT D LEVEL AND PEG INTERFERON INJECTION

@stef2011.   Heard you mention that sufficient vitamin d level is good while on pegylated interferon injection . My viral load was 7998IU/ml  and ALT 10.9IU/L , fibroscan show 7.8kpa f1/f2 . My doctor said she I should start pegylated interferon treatment immediately and I have the first shot two days ago. She said we will do HBV DNA test after 12week  after the treatment and if the virus is still detectable then I will switch to tenofovir and stop interferon . I did vit d level test and my result is 20.1 ng/ ml (25-OH)   1) is my doctor right to start interferon treatment (NOTE I have use interferon in 2010 which help me to seroconversion to hbeag negetive ).      2) what can I do about my vit d level 3) should I follow my doctor advice to wait and see the effect after 12 weeks on treatment or I should change doctor , please I need your good advice in other not to make a mistake in treatment I also has fatty liver the doctor gave me TOCOVID SUPRA BIO 1 tablet dialy
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Avatar universal
no use it anyway the fact it doesn t respond well is the same as genotype D and little less C, just a chart from the most responders to the less ones
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Avatar universal
@stef2011.  Genotype E does not respond well to interferon ,? Please what do you advice me to do now.   1) should I stop interferon and start tenofovir  ? My viral load is 7998IU/l fibroscan f1/f2
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Avatar universal
http://www.vitamindwiki.com/No,+do+not+need+9,000+IU+of+vitamin+D+to+get+most+people+above+20+ng+%E2%80%93+Oct+2014

Original error paper - Oct 2014

A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D

Nutrients. Oct 2014; 6(10): 4472–4475.Published online Oct 20, 2014. doi: 10.3390/nu6104472
Paul J. Veugelers and John Paul Ekwaru
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Avatar universal
http://www.vitamindwiki.com/Vitamin+D+Recommendations+around+the+world+-+IU+and+ng

and this is not for chronic hbv carriers or damaged livers, this is mainly for healthy

just browse medhelp hbv community from 2010 there are all study links and all members supplementation and results especially because the vit d levels are correlated to immune response and inverse to hbvdna
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Avatar universal
when the liver is very damaged like cirrhosis the liver cannot produce vit d anymore, in these cases the doses like 300.000-500.000iu are also not sufficient because they increase vitd25oh of 1-5ng/ml only.......so there is no max dose, everyone must start with 10.000iu which is normal dose and half what we make with the sun per day which is around 20.000iu and then see if the liver can make it

the vit d we take by supplements need many transformations t other substances that go into tissues and our organs are damaged, receptors modified by pathogens, so for those with no damage 5000 to 10.000iu are sufficient fr those with damage the dose needs to be adjusted by monitoring levels of 25oh/intact pth

there is also recovery of course, for example before pegintf i needed 150.000iu daily today 20.000iu daily

another very important note:
for doses over 10.000iu daily an exert doctor on vitamin d (rare to find) is needed for monitoring of calcium and so on and also no dairies diet, 2.5L of water dily.for doses less than 10.000iu nothing is required
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Avatar universal
genotype E is from africa/nigeria, it responds bad to peg unfortunately
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Avatar universal
with 1000iu you better drink water it could make more to your vit d pathways.....

we already taking vit d from years here the minimum to start is 10.000iu then after 3-4 months you check vitd25oh and intact pth in particular and see if you need more or little less

look for brands like healthy origins 10.000iu, nowfoods 10.000iu, biotech 5000iu.we already checked brands for quality many brands have bad oils with vit d3, oliv oil is the best because other oils can become rancid and give problems/sides (rancid oils are very bad oxidaizers).biotech is very good because it is the only one with water soluble powder so very absorbable.maxhealth labs makes it liposomal but it costs too much

purity pride, you mean puritan.com?they have all types, 10.000iu is the cheapest but oils are not oliv oil
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Avatar universal
you have also to look for doses for chronic illnesses and hbv not doses for healthy persons, viruses hijack vit d pathways and your doses cannot be the one i mentions you have to test vitd25oh and intact pth to know what you need and not vitd25oh
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Avatar universal
all studies were wrong on purpose, the minimum doses are:
pregnancy 6000iu
adults 7000-10.000iu
deficiency less than 10ng/ml need 1 million iu single dose according to guidelines

avoid anything from US institutions, corrupt and all doses wrong, refer to european or asian studies less corrupt
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Avatar universal
I'm not stef2011 but just chiming in -

I am also on a 1000 IU tablet for D3. I take it once in morning and once in the evening. I also take a normal multivitamin that has 700 IU D3 as a part of it.

From what I've read 1000 IU *sounds* like a lot but it's really a low dose. You and I could probably take higher doses safely if we wanted to.
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Avatar universal
@stef2011 what is intact pth? And the vit D3 capsule that I found here is 1000 IU from purity pride . What is your advise now
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Avatar universal
@stef2011 thanks i didn't do genotype test but most carrier here are genotype E I will be posting my result every 12 weeks to monitor the response. There is still a long way to go for chronic hep b carrier here . I show my fibroscan result to one doctor today he told me that there is nothing like fibroscan in medical line that the only test to access liver damage is through liver biopsy . He even told me I don't need treatment with 7998IU/ml viral load . That how they are killing people with wrong approach
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Avatar universal
Another stupid doctor you should base response to 24 weeks hbsag and hbvdna.12weeks if you know genotype, hbsag and hbvdna, i guess genotype has not been checked.....

i dont remember if there are stopping rules on hbvdna, not that useful to understand peg response
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Avatar universal
@sorte it is not the same doctor . This is a new doctor my question weather I can still use pegylated interferon the second time with HBV DNA OF 7998 IU/ml
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Avatar universal
Is it not too early to stop peginf if hbv dna detectable in week 12 ? I don't remember anything like this in any guidelines but I may be wrong.
Is it the same "doctor" who stopped peginf after 24 weeks because you HBe seroconverted ?
Helpful - 0
Avatar universal
You can take one single 50.000iu dose and then 10.000iu daily, recheck vitd25oh and intact pth by 4 weeks, look at intact pth to be lowest norm more than vitd25oh
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