Very Low HbsAg and low viral load , should I take medication ?

[Sami19]

Dear forum experts,

Ive been a chronic hepb carrier for years , my results were always as per the below

HbeAg : negative
HbeAb : positive
Normal liver test
Low vit D
Fibroscan was normal
Low viral load < 100iu/ml
Never done HbsAg qunatitative untill last week and here is my current result

Hbv viral load : 27 iu/ml
Hbsag : 122.9 iu/ml
All liver function tests are normal

Does the low HbsAg result suggests that i can take interferon or something else ? Should i start immeditly , is the fact that Im hebeAg negative affects my choice of medicine ?

Please let me know what do you think

I'm a healthy 38 years old male , middle eastern. Im currently taking 50k iu vit d bills once a week but have not checked it yet.

[coolnaresh]

My wife with HBsAg that is first test value is 7010 , after 2 months it will be 483.82 iu/ml. those tests are CMIA tests Remaining alla test are normal. But I am not suffer with that virus. My dought is it is cureble or not we dont have any childrens please help me sir. first test date is 18/04/2016 and second test date is 27/06/2016. Please help me......

[Aduiski]

On your place I would just check the genotype...and only if it is "A" I would consider trying Pegasys...if it is some other type I would just stay put for right now and don't take any medications but instead monitor ALT and DNA every 8-12 months.

[Sami19]

thanks sorte ,  should I take peg interferon ?  is this the  right one for me ? should I take it as per the normal  once a week and then keep monitoring HbsAG levels ? or just take once and see how low is HbsAg gets to ?

my fibro scan was F0.  I don't know the kPa

[sorte]

Interferon is a serious drug an it may be dangerous to take it without doctor's surveillance. Many blood tests need to be done before starting therapy. Therapy usually lasts 48 weeks, one injection per week.

[stef2011]

Vit d must be taken daily, not weekly

[Sami19]

Thanks stef , i will check my vit d levels and adjust the dose , can you please comment on my above qiestions ( medication risk)

[sorte]

maybe Sami should check HBsAg again in a few months since starting the supplementation ? There is a chance that he was vid d deficient the whole life so his immune system didn't work 100% efficiently.

[sorte]

You are typical inactive carrier and you've got decent chance that your body will clear hbv without any treatment but no one can tell you if it will happen in one year or in 10 years.
If you will try interferon there is high chance to clear, but no one can guarantee it and you need to also remember about possible side effects.

[Sami19]

Thank you , what are the implications of taking medication apart from side effects ? In other word is there a risk of waking up the virus or creating mutants of it , drug resistance ?

Which medication should i take , how often and for how long ? I dont think any doctor will agree to write a hepb medicine for these lab results.

[sorte]

With your excellent results you'v got low risk of any liver related complications.
Btw what means fibroscan normal in your case ? F0 ? F1 ? How much kPa ? You're right, most doctor won't prescribe any medicine with such good results.

With interferon that is a small of risk some side affects, but usually they are temporary only during therapy like tiredness, flu like sympthoms etc.. Read on internet there is a long list of possible side effects. There's no risk of creating virus drug resistance mutations. From the other side with such low HbsAg you've got high chance of loosing hbsag and developing antibodies.

With nucleoside analogues there is a low chance of kidneys and bones issues but in your case, very low viral load no sense to take it.