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Viread (Tenofovir) or Baraclude (Entecavir)
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Viread (Tenofovir) or Baraclude (Entecavir)

Hi all,

I'm getting ready to begin treatment within the next month and need some help in deciding which treatment option to go with. Any suggestions are appreciated.

Thanks.
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6 Comments Post a Comment
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Avatar_m_tn

tenofovir little more potent antiviral activity especially on hbe neg, no resistance, possible sides effects after decades of use

entecavir no sides, about 1% resistance at 6 years
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Avatar_m_tn
how is tenofovir if it use in case of entecavir resistance ?
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Avatar_m_tn

from some reports it can t complitley make hbvdna und.entecavir makes about 3 or more mutants at the same time
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Avatar_f_tn
"from some reports it can t complitley make hbvdna und.entecavir makes about 3 or more mutants at the same time"

Do I understand right, that if there is resistance towards entecavir, it means that tenofovir will not work? Could you please give the link with mentioned reports?
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Avatar_m_tn

the highest danger of these mutants from entecavir, lamivudine, adefovir, telbivudine is that like occult hbv they promote liver cancer even if hbvdna is made undetactable, this is why i am so pro combo and i am using alinia, vitamin d and cholesterol lowering, because if you do get the mutant it is not a matter of hbvdna und you get in deep sh** anyway and drug sellers have little to lose they will sell you 2 drugs instead of one tenofovir+ftc and  liver cancer drugs which are extremely expensive....

by the way also interferon monotherapy is very dangerous because of the rate of hbsag mutations, these are also very dangerous because of development of occult hbv which can lead to cirrhosis and liver cancer with no detactable hbvdna with low sensitivity pcrs and normal ast/alt.the rate of hbsag mutants are not very high but as for entecavir those who get it are in deep sh**

i think the best way is to suppress hbvdna as eraly as possible, 6months maximum or combo, just to stay on the extra safe side, as HR (hepatitis researcher) posted once on this forum

there is very little data about what happens to etv resistance under tenofovir and how long suppression can be manteined, but if hcc/cirrhosis prevention doesnt work with the presence of lam mutants there is no point in hbvdna undetectability
http://depts.washington.edu/hepstudy/hepB/mgmt/treatment/discussion.html
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Avatar_m_tn

i think that they should have used combo only from the begining instead of experimenting on patients making a lot of damage on monotherapies that are all a total failure as regards hbv clearance

what makes also very mad is that we have so much evidence that interferon+potent nucs like tnf, etv or telbivudine lower hbsag a lot but there are almost no trials on this
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