the highest danger of these mutants from entecavir, lamivudine, adefovir, telbivudine is that like occult hbv they promote liver cancer even if hbvdna is made undetactable, this is why i am so pro combo and i am using alinia, vitamin d and cholesterol lowering, because if you do get the mutant it is not a matter of hbvdna und you get in deep sh** anyway and drug sellers have little to lose they will sell you 2 drugs instead of one tenofovir+ftc and liver cancer drugs which are extremely expensive....
by the way also interferon monotherapy is very dangerous because of the rate of hbsag mutations, these are also very dangerous because of development of occult hbv which can lead to cirrhosis and liver cancer with no detactable hbvdna with low sensitivity pcrs and normal ast/alt.the rate of hbsag mutants are not very high but as for entecavir those who get it are in deep sh**
i think the best way is to suppress hbvdna as eraly as possible, 6months maximum or combo, just to stay on the extra safe side, as HR (hepatitis researcher) posted once on this forum
there is very little data about what happens to etv resistance under tenofovir and how long suppression can be manteined, but if hcc/cirrhosis prevention doesnt work with the presence of lam mutants there is no point in hbvdna undetectability
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