http://ortho.ucla.edu/body.cfm?id=208
Non-Classical Effects of Vitamin D and immune system boost
"vit d is needed to activate immune system cells" - this will result distroing more cells (so implicitly some fibrosis) and the results say that vit d protect us against fibrosis. - (is something wrong ? )
vit d added to milk is not the natural type but the synthetic type, and even if it was d3 the quantity is still very very low.this is the only thing i can say about milk with vit d
vit d is needed to activate immune system cells, with no vitamin d immune system cells do not activate and remain dormant whatever happens to our body, this is something researchers saw in vivo too by microscope no need to add anything to this
less evident but there is proff of this from many many studies both in vivo or vitro.
from gcmaf studies in vivo:
vit d alone is not enough to activate dormant immune cells, gcmaf is also needed
also vitamin d receptors can have more or less response to vit d for activation, FF/bb max attivation and ff/BB very weak activation
people with ff/BB has higher development of cancers, osteopenia, kidney diseases
the first link - look that it not agree that FDA is putting vit D in the milk ... - it is done by an Australian researcher. (it is some how to technical for me, still need to study to understand what is all about)
I still don't understand how this vit d and interferon synergy works, even if i read the study that demonstrate this.
vit d will slow protect against fibrosis, so will slow the inflamatory response (some study say that, Vitamin D confers an immunosuppressive effect).
on the other hand interferon will increase inflamatory response (interferon will base on the imune system).
so I try to understand how this works :) ... i will try to write this to a researcher.
i just saw the first one, it looks just out from FDA and drug makers...just claims but i see no human trials to prove what they say while we have hcv human trials to prove increase of svr with interferon where vit d with immune modulating drugs resolves the disease
to me that's just rubbish until i see a large human trial to prove it
for another forum i receive the following answer.
"...Interesting about cause and effect. Here are publications that say exactly that - low Vitamin D levels are not the cause of disease but the result of it. Even goes so far as to say that since Vitamin D is a type of steroid, it can make people feel better but only temporarily - it masks the disease which gets worse over time.
http://trevormarshall.com/BioEssays-Feb08-Marshall-Preprint.pdf
http://autoimmunityresearch.org/transcripts/AR-Albert-VitD.pdf
"
what do you think ?
I am 43 years old. You can see my history on this link.
http://www.medhelp.org/posts/Hepatitis-B/Results-after-about-2-months-of-VitD3-5000iu-and-heptec-/show/1601656
I wanted to start the treatment but the 2 doctors that I am consulting have no idea of latest researches and latest news about hbv. I have to read and understand as much as I can and have to choose the best treatment possible for me.
stef2011 is also helping me a lot and I'll probably start the treatment in march after the tests.
your doc is wrong you should wish to have high alt while hbvdna und, that means viral clearance and lowering hbsag by killing of infected cells, anyway this is almost non-existent with antivirals
you should plan interferon add-on after 2-3 years of hbvdna und
check our gcmaf/maf314 probiotic posts often since it may be a cure for osteopenia
Hello,
MAy I know how old you are, not to offend.
I am going to be 58 years old, HBeAg-ve, HBVDNA of 27,400 IU/ml, ALT of 30 and AST of 31.
My doctor wanted to treat me since beginning of last year but like everyone else,I postponed on it and started only last Nov 11, 2011(barely 2 1/2 months ago). I decided to go on treatment due to my age, with chances of getting HCC higher. And that even though I have normal ALT doesnt mean there is no chance of HCC. And that cirrhosis or no cirrhosis, chance of HCC is there.
After a month of etv, (etv instead of tnf because I have osteopenia) my HBVDNA went down to 326 IU/ml. After 2 months of etv, i.e. I had a blood test done on Jan 4, 2012, my HBVDNA is now < 20 IU/ml. Although my ALT went up to 33 from 30.
My blood test will be checked again on April 6, before my next appt with him on April 16. N.B. Acc to my doctor, it will be a monthly blood test for 2 months after starting with antiviral treatment, and it will be every 3 months thereafter.
ETV definitely is suppressing viral replication but I wish USA has the fibroscan and HBSag testing to see what is going on with my liver.
We should remember that our liver is still infected, i.e. ccc DNA.
I am taking Vit D3 and Vit B complex to help my liver, hopefully, and to help with viral treatment since Vit D3 helps with antiviral treatment; I also take Caltrate for my osteopenia and Vit C sometimes.
My doctor told me it will take sometime to bring back ALT in the teens, but I will patiently wait and do this treatment religiously as prescribed and try to eat healthy as much as I can and of course PRAYERS is the most important thing.
Good luck to you and to all of us HBVers.
Thanks for the information. In March I'll test everything that stef mentioned, vitD3,calcium,hbvdna,hbsag quantities, alt/ast,frbroscan. As I keep taking vitD3 about 8000iu everyday, it will surely go up in March. It's interesting to see the rest of the results.
Vitamin-D supplementation was reported to improve the probability of achieving a sustained-virological-response when combined with antiviral treatment against Hepatitis C Virus (HCV). Our aim was to determine the in-vitro potential of vitamin-D to inhibit HCV infectious virus production and explore the mechanism(s) of inhibition. Here we show that vitamin-D(3) remarkably inhibits HCV production in Huh7.5 hepatoma cells. These cells express CYP27B1, the gene encoding for the enzyme responsible for the synthesis of the vitamin-D hormonally active metabolite, calcitriol. Treatment with vitamin-D(3) resulted in calcitriol production and induction of calcitriol target gene CYP24A1, indicating that these cells contain the full machinery for vitamin-D metabolism and activity. Notably, treatment with calcitriol resulted in HCV inhibition. Collectively, these findings suggest that vitamin-D(3) has an anti-viral activity which is mediated by its active metabolite. This anti-viral activity involves the induction of interferon signaling pathway resulting in expression of interferon-β and the interferon-stimulated gene, MxA. Intriguingly, HCV infection increased calcitriol production by inhibiting CYP24A1 induction, the enzyme responsible for the first step in calcitriol catabolism. Importantly, the combination of vitamin-D(3) or calcitriol and interferon-α synergistically inhibited viral production. Conclusion: This study demonstrates for the first time a direct anti-viral effect of vitamin-D in an in-vitro infectious virus production system. It proposes an interplay between the hepatic vitamin-D endocrine system and HCV, suggesting that vitamin-D has a role as natural anti-viral mediator. Importantly, our study implies that vitamin-D might have an interferon sparing effect thus improving antiviral treatment of HCV-infected patients. (HEPATOLOGY 2011.)
http://www.researchgate.net/researcher/39662381_Romy_Zemel
o studdy of one of the mentioned dr (Romy_Zemel)
the problem with these studies is they have not determined the optimal range with maximum antiviral effect, but i have collected some observations:
dr.breadstreet, resercher using gcmaf on austim and cancer.he i using high dose vitamin d around 8000-9000iu daily on patients and he is getting a response of 80% on autism and 100% on cancer.
on vitmin d he says i suppose higher ranges close to 100ng/ml with calcium balance have higher results
vitamin d use on cancer patients, the ranges around 90-100ng/ml have higher results
a study i just read some days ago, vitamin d works on cancer prevention but only at the higest doses which require calcium and vitamin d close monitoring, they dont say value but i guess it is around 90ng/ml if monitoring is a must
my sister getting lower alt at 40 despite high hbvdna at around 150.000-200.000iu/ml
i think we just have to discover the best ranges of vitamin d and we may do this ourselves in this community with close monitoring of vit d, calcium, ast/alt, hbvdna and hbsag quantities better than researchers
no, not yet, but I will try to get a link or to get in touch with the dr.
thank you this is very good study, this definitely makes vit d a must for anybody with liver disease, be it hbv, hcv or fatty liver
do you have a link for the full study on the journal?
you are correct it discuss regarding C, but "They also found that a system for actively producing vitamin D is found in liver cells and can activate the immune system and repress the virus." - this I think it apply also to B and also "The research showed without doubt that vitamin D functions in the liver cell, and it causes an increase in naturally produced interferon "
This looks very promising. But the research is based on Hep C, hope it applies to B as well.