I just received my new lab results and am very disappointed:( I
guess I am precore. I was hoping for my DNA to stay undetectable like last year but it actually has really increased. I wonder if there is a fault in the lab b/c I didn't receive my dna results immediately (in fact quite a delay) from when I received the other results.
Anyhow, here is the results and here are my questions
1. Do I need to go under any treatment, if so, what kind? Do you recommend I just try something natural first. I am kinda of scared to go on any antiviral and stay with it for life.
2. Why is there a low decrease on ALT and AST and all of a sudden a high increase in DNA? Shouldn't my ALT and AST also increase with the DNA?
3. Since I am precore mutant (as the results do show), and my AFP also went up, am I at serious risk for liver cancer? Also, what do you think causes the AFP to rise, the DNA levels?
Am I in the immune-tolerant stage?
Here are the results from last April and the new results as of today.
everything else also normal *didn't check dna yet*
Prot Total 7.0
ALK PHOS 75
BILI TOTAL 0.3
BILI DIRECT <0.07
HBV DNA PCR TESTING 842 iu/ml and 1550 copies/ml
(Everything else normal) didn't check DNA yet*
ALK 96 (all normal)
DNA undetectable <100 copies
NEW RESULTS of TODAY
DNA HBV DNA, QN, PCR
(IU/mL)----------------------------------------15300 IU/mL (<100)
There is nothing I see out of the ordinary here. Studies have shown that over a period of time you go from undetectable to small detectable in DNA count for an inactive carrier.
Don't quote me on this number but I believer precore mutants would generally have well over 100,000 DNA copies (and usually millions). Precore mutants would also have raised AST/ALT which you don't have.
Your AFP is notthing to worry about at those levels and it just seems you are a normal inactive carrier.
Also the DNA test usually does take a couple of weeks to get back so nothing unusual there.
"(i) Chronic HBV carriers with no detectable HBV replication. Small amounts of HBV DNA may however be detected in these patients with recently developed highly sensitive PCR-based assays. Ongoing studies are aimed at determining the threshold above which HBV replication should be considered clinically relevant."
A few years back, the best tests were only able to detect above 150,000.
Treatment with antivirals is not recommended for your very low viral count. It will ebb and flow (detectable to nondetectable) but very low.
You should get treatment if your AST/ALT rises and your DNA rises over 100,000.
DNA undtectable does not mean that you have no virus in you. As long as you are S antigen positive that means the virus is replicating (S antigen is released when the virus reproduces).
It means you have little virus circulating in your blood but it still is replicating in your liver. There is a correlation with DNA in your blood and damage to your liver but not in the low numbers you have. Some people have counts in the billions.
Its a cycle. Sometimes the virus becomes dtetecble and then it goes undetectable and so on.
This site complies with the HONcode standard for trustworthy health information.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.