Aa
Zocor simvastatin
Zocor simvastatin has been found to act against hbv in a different way that antiviruses, has anybody tried it?especially inactive carriers that don't need normal antivirals because they have no virus replication.
i might try it because i have a little high cholesterol too but i would like to see others that use it because they have high cholesterol and hbv
i might try it because i have a little high cholesterol too but i would like to see others that use it because they have high cholesterol and hbv
check also who is making the research on simvastatin, and that liver damage has been removed recently, at least here in italy
check carefully there is no prof of damage on who is making treatment, my dad is making it for cholesterol and treatment is for all his life
of course it is better to have your liver healthy and as i have said very clear only for inactive carriers
active carriers is a different story
Hi,
If you check the PDr (physician's desk reference) or any literature on statins -- you will find that part of the spectrum of side effects is liver damage, hepatic failure and death. So, please don't buy into any information to the contrary, i.e. that it can now aid in the treatment of the very organ that it is widely known to destroy.
Good luck and God bless.
If you check the PDr (physician's desk reference) or any literature on statins -- you will find that part of the spectrum of side effects is liver damage, hepatic failure and death. So, please don't buy into any information to the contrary, i.e. that it can now aid in the treatment of the very organ that it is widely known to destroy.
Good luck and God bless.
yes i think so, i will wait for furthur studies too probably.
but there is somebody who has tried this medicine already for sure because both high cholesterol and hvb carriers are common
but there is somebody who has tried this medicine already for sure because both high cholesterol and hvb carriers are common
Any new protential new treatment is exciting. It didn't say how it acts against HBV. I would be cautious on this and wait for more studies.
The thing we learned now is that it's important to see if (and if so, how) HBV would try to escape this drug control. HBV is always tinkering to escape control. Remember LAM was the miracle drug in the beginning. Doctors were prescibing it left and right....then came the consequences. It was the Wild-Type before. Our immune system eSeroconversion process led some to PC or BCP mutants. Antiviral treatment led some to other mutants. How will this go if this becomes a legit treatment option? Who knows at this point.
I've learned to be cautious. If I am an inactive carrier with very low viral activity, I'll probably leave it along. Why throw stones at the beast when it's sleeping.
The thing we learned now is that it's important to see if (and if so, how) HBV would try to escape this drug control. HBV is always tinkering to escape control. Remember LAM was the miracle drug in the beginning. Doctors were prescibing it left and right....then came the consequences. It was the Wild-Type before. Our immune system eSeroconversion process led some to PC or BCP mutants. Antiviral treatment led some to other mutants. How will this go if this becomes a legit treatment option? Who knows at this point.
I've learned to be cautious. If I am an inactive carrier with very low viral activity, I'll probably leave it along. Why throw stones at the beast when it's sleeping.
that's a report from 58th Annual Meeting of the American Association
for the Study of Liver Diseases (AASLD 2008)
October 31 - November 4, 2008, San Francisco, CA
i strongly stress that inactive carrier has no virus replication and no or very little liver damage (hbv dna lower than 104 or less)
for the Study of Liver Diseases (AASLD 2008)
October 31 - November 4, 2008, San Francisco, CA
i strongly stress that inactive carrier has no virus replication and no or very little liver damage (hbv dna lower than 104 or less)
http://www.hivandhepatitis.com/2008icr/aasld/docs/112108_c.html
i would consider this only for inactive carriers with no virus replication at all, it is better to wait furthur studies for those who has virus replication and i don't think this is a strong cure for them.
info on the drug :
http://www.druginfonet.com/pi_mfr/ppi/merck/zocor/zocor.htm
most notable segments :
Patients with liver problems: ZOCOR should not be used by patients with active liver disease or repeated blood test results indicating possible liver problems.
Liver: About 1% of patients who took ZOCOR in clinical trials developed elevated levels of some liver enzymes. Patients who had these increases usually had no symptoms. Elevated liver enzymes usually returned to normal levels when therapy with ZOCOR was stopped.
In the ZOCOR Survival Study, the number of patients with more than one liver enzyme level elevation to greater than 3 times the normal upper limit was no different between the ZOCOR and placebo groups. Only 8 patients on ZOCOR and 5 on placebo discontinued therapy due to elevated liver enzyme levels. Patients were started on 20 mg of ZOCOR, and one third had their dose raised to 40 mg.
Your doctor should perform routine blood tests to check these enzymes before you start treatment with ZOCOR and periodically thereafter (for example, semiannually) for your first year of treatment or until one year after your last elevation in dose. If your enzyme levels increase, your doctor should order more frequent tests. If your liver enzyme levels remain unusually high, your doctor should discontinue your medication.
http://www.druginfonet.com/pi_mfr/ppi/merck/zocor/zocor.htm
most notable segments :
Patients with liver problems: ZOCOR should not be used by patients with active liver disease or repeated blood test results indicating possible liver problems.
Liver: About 1% of patients who took ZOCOR in clinical trials developed elevated levels of some liver enzymes. Patients who had these increases usually had no symptoms. Elevated liver enzymes usually returned to normal levels when therapy with ZOCOR was stopped.
In the ZOCOR Survival Study, the number of patients with more than one liver enzyme level elevation to greater than 3 times the normal upper limit was no different between the ZOCOR and placebo groups. Only 8 patients on ZOCOR and 5 on placebo discontinued therapy due to elevated liver enzyme levels. Patients were started on 20 mg of ZOCOR, and one third had their dose raised to 40 mg.
Your doctor should perform routine blood tests to check these enzymes before you start treatment with ZOCOR and periodically thereafter (for example, semiannually) for your first year of treatment or until one year after your last elevation in dose. If your enzyme levels increase, your doctor should order more frequent tests. If your liver enzyme levels remain unusually high, your doctor should discontinue your medication.
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