i am 32 yrs old. i have HBsAg reactive known by a letter from hospital by blood donation. i got checked by the doctor
& HBeAg in negative and anti HBeAg is positive anti HCV is also negative. my HBV-DNA quantitative report is " SAMPLE IS NEGATIVE FOR HBV DNA". My question is am i having hep b virus and after how many months HBsAg should be non reactive. i will be greatful to your response
you do have hbv as long as hbsag is positive, hbvdna means nothing.if hbcab igm is negative it is cronic hbv, if it is positive it is acute and you need to check if hbsag is not decreasing fast it has become cronic
you need to check hbsag quantity by abbott architect in iu/ml unit, if you find hbsag lower than 1500iu/ml you can easily clear hbv by interferon+tenofovir in 96weeks combo treatment
I don't think we have treatments cure for Hep as of now but we have medicines to control this Virus. As Stef said above if hbsag lower than 1500iu/ml you can easily clear hbv by interferon+tenofovir in 96weeks combo treatment
Did you check your HBSag, HVDNA ,ALT,AST and AFT ?
i am kru from india.i am one of the seafarer.doctor found that i am having hbeag.the value is 4.9.i am using tenvir tablet.is it possible to become the value is below 1.how long it will take .please advice me .
hi stef i am kru from india, i am having hbe ag positivie.the value is 4.9....i am using tnvir tablet. how long it will take to below 1.which one is very difficult to bring the value below 1. hbeag or hbsag????
In the natural history of hepb, there are several phases. HBeAg positive is the first phase. In this phase, the virus is replicating, viral load(hbvdna) will be high. There may or may not be damages to the liver. As we get older, some will naturally become HBeAg-ve naturally, others may not and there may be ongoing damage to the liver. So doctors will prescribe medication to stop the virus from replicating, thereby stopping further damage to the liver, and even allow the liver to heal. This is a long term process. After several years of medication, HBeAg may turn negative. When HBeAg is negative, the virus should stop replication either by the medication or by our own immune system.
Yes, it is possible to revert from HBeAg negative to positive again, but as stef2011 said, it is not important, the main thing is keep viral load low, naturally or by medication, to stop any damage to the liver. Then we can wait for a cure or more permanent treatment to come along.
Wish I know the answer. Personally, I think any reversion from HBeAg negative to positive should only happen when a) the conversion was natural in the first place, before development of e-antibodies. Eventually, the seroconversion should be stable with the development of e-antibodies; b) when the conversion was induced by medication and the patients then stop medication too soon. This may mean going back to medication again.
Finally, the re activation that we should keep watch for is when HBeAg remains negative, but hbvdna rises. This is then due to the virus having mutated and treatment is then required.
Yes, even when there is anti-HBeAg. The virus has mutated ( a great proportion) to a form that no longer produces HBeAg. This is HBeAg negative chronic hepatitis and was only realized only 10 years ago. It can still be treated very well by all the existing HBV medications.
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