about hepatitis B

Dear sir/madam,
                      i have been a patient of hepatitis B carrier from 2004 during this time i visted defferent doctors of hepatitis,and they tested my blood

HBsAg------------ Positive-------Repeated--- 12 time upto now same result
HBeAg----------- Negative-------Repeated---12 time upto now same result
PCR by DNA-------Negative------ Repeated 3 time upto 2008 same result
ALT-------------- always normal

                                             NOW
in 2009  dear sir i have used some hemopetic medicine for clearing surface antigene and also used sabivo teblets for three months now when i test my blood i got the test result positive for PCR DNA other remian same.i also done ultrasound of liver which show portal vein measure 1.5 cm
doctor impression is ( cirhosis liver)

my question is that why my PCR become positive after so long time .and i am useing entcavir is it benificail for me for two yeas doctor say.will my PCR will be nagtive again should i do exercise daily running  when i repeat test again .
thanks

[stef2011]

your doctors are crazy and used wrong drugs from start, sabvivo is a crap drug on cirrhosis because it makes resistance and never never be used as a firstline drug on any hbv carrier

you do need a resistance test and use of a combo therapy because a resistance mutation can be deadly on cirrhosis, the best drug for you is tenofovir+entecavir combination and you should monitor creatinine from start and then every week first month and if no rise every month

since you started with sabivo you might have resistant mutants and the only drug active on all mutants is tenofovir, the use of entecavir combo will prevent any resistance and make the tretment very safe and potent

[stef2011]

what is your hbvdna pcr on entecavir and how long did you use entecavir and sebvivo

also look for a better doctor, the one who prescribed drugs is absolutely a danger for you

[stef2011]

just to understand your scenario:
sebvivo makes a mutant that makes lamivudine, entecavir useless, every doctor aware of hbv knows this

tenofovir is active on all mutants, and might be less potent only if q215s mutant from lamivudine is present or adefovir mutant is present so in your case it should work.you cannot stop entecavir but use a combo entecavir+tenofovir, this is called add-on and this is the only good strategy with resistance mutations