interesting point arises here Stef ...... Being semen/sperm has DNA only is it quite possible that it carries cccDNA too right? so intercourse may cause transmission of virons even without tissues damage?
in case patient cleared his Bdna and surface antigen during therapy , there would be no any problem even if cccDNA would be present, as cccDNA is not infectious as per your version even if it replicate its replica would be covalently closed circular dna only? which cant do any harm......plz give some light on it
when hbsag is und and hbsab>10miu/ml the infection is over, cccdna is und
even if some cccdna remains (no possibility to detect it because too low) it can t do nothing but wait to be destroyed by cell death/cell division.virions even if formed cannot infect other cells because hbsab blocks entrance to cells, so the virions are killed in a very short time
Gr8.... Stef in case pt is on therapy his HBV DNA is Undetectable currently with HBsAg levels around 1000IU, pt want to switch over combo IM and antiviral but his ALT is normal, can we stop the antiviral therapy prior to IM combo for some time to raise his ALT? coz ALT should be raised if therapy considered with ifn and antiviral like Tenofovir.
Combo i mean administration of two drugs at one time ( Immunomodulator- i.e IFN with Tenofovir ) to focus HBsAg , which may work in synergistic manner,One planned to enhance immune system and another to protect from any Viron replication.
What about ALT???? can we stop antiviral drugs for a while to take a chance for ALT surge
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