antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells

http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=751

Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells.

i am not expert on lipids cellular methabolism but since these liposomes are not available yet doesn anybody know a safe way to lower cellular cholesterol to make hbv life a little harder now?

red yeast rise (which contains naturally lovastatin, simvastatin and some other statins), simvastatin or other more powerful statins?

is simvastatin the most potent since used already with interferon and studied in vitro with antivirals (most potent sim+etv 300:1)
aslo what is the meaning of 300:1?150mg sim+0.5mg etv?maximum dose of sim is about 80mg i guess 150mg is toxic

[stef2011]

http://www.jiasociety.org/content/13/1/25

study in vivo that links cholesterol- hiv drugs response-immune response.

Background
In vitro studies suggest that reducing cholesterol inhibits HIV replication. However, this effect may not hold in vivo, where other factors, such as cholesterol's immunomodulatory properties, may interact.

Methods
Fasting blood samples were obtained on 165 people living with HIV at baseline and after 24 weeks on highly active antiretroviral therapy (HAART). Participants were classified as hypocholesterolemic (HypoCHL; 150 mg/dl) and were compared on viro-immune outcomes.

Results
At baseline, participants with HypoCHL (40%) exhibited lower CD4 (197 ± 181 vs. 295 ± 191 cells/mm3, p = 0.02) and CD8 (823 ± 448 vs. 1194 ± 598 cells/mm3, p = 0.001) counts and were more likely to have detectable viral loads (OR = 3.5, p = 0.01) than non-HypoCHL controls. After HAART, participants with HypoCHL were twice as likely to experience a virological failure >400 copies (95% CI 1-2.6, p = 0.05) and to exhibit <200 CD4 (95% CI 1.03-2.9, p = 0.04) compared with non-HypoCHL. Low thymic output was related to poorer CD4 cell response in HypoCHL subjects. Analyses suggest a dose-response relationship with every increase of 50 mg/dl in cholesterol related to a parallel rise of 50 CD4 cells.

Conclusions
The study implicates, for the first time, HypoCHL with impaired HAART effectiveness, including limited CD4 repletion by the thymus and suboptimal viral clearance.

[stef2011]

all this thing about cholesterol have come to mind because my sister has been at the hospital for a bad flu virus that attacked her stomach, she has been kept 4 days with no food/no water but continuous infusion of water+glucose.

we saw that her cholesterol lowered to tot chol 150 and ldl 90, low ranges about like my father who takes sim for high cholesterol/stroke prevention.also alt/ast lowered to very low levels too bad we couldn t see hbvdna/hbsag levels which might confirm lower hbv activity

[stef2011]

https://docs.google.com/viewer?a=v&pid=explorer&chrome=true&srcid=0B_yFgxI8KNcRNjUwMDRkYzgtYzE4Ny00YmI0LWIyOWUtOTI0ZDZkOGUyYzBi&hl=en

i have no time to read this now but i think there might be good info in it

[stef2011]

everything seems to work with lipids/sugars as regards envelopped viruses, but also immune system and cancer are linked to it, many studies have confirmed lower liver cancer incidence with sim and diabetes drug Pioglitazone, and all have also hbv antiviral activity

http://archive.mail-list.com/hbv_research/message/20100809.134554.cbb98033.en.html

Conclusion: These findings suggest that chronic administration of TZD has anticancer activity in the liver via inhibition of NPM expression and indicate that these drugs might be useful for HCC chemoprevention and treatment. HEPATOLOGY 2010.

[cam4930]

stefano,

I think exercise alone probably won't do too much of cholesterol. Diet is probably more effective. I recently am very successful in dropping body weight by diet. My blood pressure was high about this time last year. Its highest was 150/95. My weight was ~155 - 160 lb. Almost I was about to take blood pressure drug, but decide to try variety of good ways first. The body weight is the first target. Here are things I did and keep doing:

1. change breakfast to oatmeal with from beggal with cream cheese (typical). I can eat less without feeling of hunger before lunch due to high fiber of oatmeal.

2. whole grain wheat bread + fruit + nuts + high fiber snack bars to maintain afternoon session. No meat usually.

3. cut high carb food (rice, etc) by half, and make up by vegetable. Meat (fish and chicken) occasionally.

4. I took fish oil, CoQ10, vitamins, garlic extract every day.

5. reduce salt intake (almost no salt in breakfast, low salt in lunch and dinner)

6. walk for 45 minutes in week days

The results are very impressive. My body weight is now at ~140 lb. Blood pressure for the last doctor visit is 123/82. I notice that my weight dropped quickly to 140 lb in a matter of ~3 month. It takes ~ 1 year to gradually drop blood pressure to the current value. I think my body must have been through some changes gradually so that my blood pressure normalizes. My guess is it must be cholesterol. Unfortunately I only will know when I can test it next time (no free tests except annually).

My purpose of posting my experiences is that I hope all hbver with high BP can do the same thing as I did, so that we don't have to take another drug, potentially poisonous to our delicate liver already bothered by hbv. If you see slow progress, don't worry. It IS slow but you will get it.

[stef2011]

To: StephenCastlecrag also

congratulations for your results, today i hit 72kg for 176cm, bmi almost 22 and waist lower than 94cm.i must say that getting low wheight by diet and excerice makes feel much much better (i say low wheight because i was high end range of normal) so this is probably the first step for all of us hbvers.
interferon, alinia, fibrosis/cirrhosis regression have very poor response if even little overwheight or with visceral fat with normal wheight, so this is absolutely a must

i have seen on internet some liposoms already on the market for vit c, what do you think are they real?

from the above research they should have antiviral activity both empty or with drugs, what do you think?
this is a link with lipo vitamin c but the problem is who checks if those are real liposoms?
http://www.livonlabs.com/cgi-bin/start.cgi/lypo-spheric/LSC30.html