anyone on Lamivudine

[Kujerry]

wondering if anyone was on Lamivudine.  My dr. prescribed it for me, but I keep hearing that I shouldn't do Lamivudine.  DNA 102000 alt around 63-68

[stevenNYer]

I posted a thread for you and those with similar questions.  Look for it.  As for  Lamivudine, I been told many time that it should not be use as monotherapy anymore due to high resistance rate.  Many primary care doctors don't understand this.  My own primary care doctor prescibed Lamivudine.  My GI specialist said no, and recommended Hepsera.  (Although now they say Hepsera shouldn't be use a monotherapy either).  I am on combo treatment, Hepsera and Baraclude.  

For Lamivudine, I read that the resistance rate is very high for those with very high DNA count.  In your case it's not that high, so maybe it's still an option.  But once resistant to  Lamivudine forms, it increases resistance developing to other HepB antivirals.  

Since you are already e-Antigen negative, have somewhat high DNA count, your high ALT show active liver damage.  You should ask for a genotyping test before treatment to determine if you indeed have a mutant strain.   You can't genotype if you have low or undetectable DNA.  I don't know which type of tx would be best, but I would think best to stay away from Lamivudine.  Although my specialist never mentioned the injections as a treatment option so far.