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artemisinin/artesunate as hbv inhibitors/kevin422 malaria treatment
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artemisinin/artesunate as hbv inhibitors/kevin422 malaria treatment


kevin422, please let us know your results on hbv using artemisinin/artesunate, as to malaria it will clear 100% with this drug since the most potent.the other drugs are pushed by doctors because produced in US although weaker and with resistance problems, it is just a market reason but the most potent/safe drug is artesunate


http://www.ncbi.nlm.nih.gov/pubmed/16122816

Antiviral Res. 2005 Nov;68(2):75-83. Epub 2005 Aug 10.
Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system.
Romero MR, Efferth T, Serrano MA, Castaño B, Macias RI, Briz O, Marin JJ.
Source
Department of Biochemistry and Molecular Biology, University of Salamanca, Spain.
Abstract
The antiviral effect against hepatitis B virus (HBV) of artemisinin, its derivative artesunate and other compounds highly purified from traditional Chinese medicine remedies, were investigated. HBV production by permanently transfected HepG2 2.2.15 cells was determined by measuring the release of surface protein (HBsAg) and HBV-DNA after drug exposure (0.01-100 microM) for 21 days. The forms of HBV-DNA released were investigated by Southern-blotting. Neutral Red retention test was used to evaluate drug-induced toxicity on host cells. The compounds were classified according to their potential interest as follows: (i) none: they had no effect on viral production (daidzein, daidzin, isonardosinon, nardofuran, nardosinon, tetrahydronardosinon and quercetin); (ii) low: they were able to markedly reduce viral production, but also induced toxicity on host cells (berberine and tannic acid) or they had no toxic effect on host cells but only had a moderate ability to reduce viral production (curcumin, baicalein, baicalin, bufalin, diallyl disulphide, glycyrrhizic acid and puerarin); (iii) high: they induced strong inhibition of viral production at concentrations at which host cell viability was not affected (artemisinin and artesunate). Moreover, artesunate in conjunction with lamivudine had synergic anti-HBV effects, which warrants further evaluation of artemisinin/artesunate as antiviral agents against HBV infection.

PMID: 16122816 [PubMed - indexed for MEDLINE]
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