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artemisinin/artesunate as hbv inhibitors/kevin422 malaria treatment
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artemisinin/artesunate as hbv inhibitors/kevin422 malaria treatment


kevin422, please let us know your results on hbv using artemisinin/artesunate, as to malaria it will clear 100% with this drug since the most potent.the other drugs are pushed by doctors because produced in US although weaker and with resistance problems, it is just a market reason but the most potent/safe drug is artesunate


http://www.ncbi.nlm.nih.gov/pubmed/16122816

Antiviral Res. 2005 Nov;68(2):75-83. Epub 2005 Aug 10.
Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system.
Romero MR, Efferth T, Serrano MA, Castaño B, Macias RI, Briz O, Marin JJ.
Source
Department of Biochemistry and Molecular Biology, University of Salamanca, Spain.
Abstract
The antiviral effect against hepatitis B virus (HBV) of artemisinin, its derivative artesunate and other compounds highly purified from traditional Chinese medicine remedies, were investigated. HBV production by permanently transfected HepG2 2.2.15 cells was determined by measuring the release of surface protein (HBsAg) and HBV-DNA after drug exposure (0.01-100 microM) for 21 days. The forms of HBV-DNA released were investigated by Southern-blotting. Neutral Red retention test was used to evaluate drug-induced toxicity on host cells. The compounds were classified according to their potential interest as follows: (i) none: they had no effect on viral production (daidzein, daidzin, isonardosinon, nardofuran, nardosinon, tetrahydronardosinon and quercetin); (ii) low: they were able to markedly reduce viral production, but also induced toxicity on host cells (berberine and tannic acid) or they had no toxic effect on host cells but only had a moderate ability to reduce viral production (curcumin, baicalein, baicalin, bufalin, diallyl disulphide, glycyrrhizic acid and puerarin); (iii) high: they induced strong inhibition of viral production at concentrations at which host cell viability was not affected (artemisinin and artesunate). Moreover, artesunate in conjunction with lamivudine had synergic anti-HBV effects, which warrants further evaluation of artemisinin/artesunate as antiviral agents against HBV infection.

PMID: 16122816 [PubMed - indexed for MEDLINE]
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Stefan  any news on this? I think I will try it. People are saying that this is in fact the most potent antiviral herb close to a real medication.

Many reports I have read that anti malaria agents work against HBV.
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What are your thoughts? What new if anything have you heard about it?  Safe dose for us - toxicity etc?
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Traditional Chinese medicine commands a unique position among all traditional medicines because of its 5000 years of history. Our own interest in natural products from traditional Chinese medicine was triggered in the 1990s, by artemisinin-type sesquiterpene lactones from Artemisia annua L. As demonstrated in recent years, this class of compounds has activity against malaria, cancer cells, and schistosomiasis. Interestingly, the bioactivity of artemisinin and its semisynthetic derivative artesunate is even broader and includes the inhibition of certain viruses, such as human cytomegalovirus and other members of the Herpesviridae family (e.g., herpes simplex virus type 1 and Epstein-Barr virus), hepatitis B virus, hepatitis C virus, and bovine viral diarrhea virus. Analysis of the complete profile of the pharmacological activities and molecular modes of action of artemisinin and artesunate and their performance in clinical trials will further elucidate the full antimicrobial potential of these versatile pharmacological tools from nature.


http://connection.ebscohost.com/c/articles/34128809/antiviral-activities-artemisinin-artesunate
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http://www.medhelp.org/posts/Hepatitis-B/Effect-of-artemisinin-artesunate-as-inhibitors-of-hepatitis-B-/show/1510589


You posted some good articles on this. Sure thing they have stopped looking into this since they give anti hiv meds.
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http://www.sciencedirect.com/science/article/pii/S0014579310003522

Also about curcumin there are good readings
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The Antiviral Activities of Artemisinin and Artesunate

Thomas Efferth,1 Marta R. Romero,3,5 Dana G. Wolf,4 Thomas Stamminger,2 Jose J. G. Marin,5

and Manfred Marschall2

Traditional Chinese medicine commands a unique position among all traditional medicines because of its 5000 years of history. Our own interest in natural products from traditional Chinese medicine was triggered in the 1990s, by artemisinin-type sesquiterpene lactones from Artemisia annua L. As demonstrated in recent years, this class of compounds has activity against malaria, cancer cells, and schistosomiasis.

Interestingly, the bioactivity of artemisinin and its semisynthetic derivative artesunate is even broader and includes the inhibition of certain viruses, such as human cytomegalovirus and other members of the Herpesviridae family (e.g., herpes simplex virus type 1 and Epstein-Barr virus), hepatitis B virus, hepatitis C virus, and bovine viral diarrhea virus. Analysis of the complete profile of the pharmacological activities and molecular modes of action of artemisinin and artesunate and their performance in clinical trials will further elucidate the full antimicrobial potential of these versatile pharmacological tools from nature.

Artemisinin is a natural product derived from the Chi- nese herb Artemisia annua (figure 1). During the Viet- nam War, Ho Chi Minh asked Mao Zedong for help, because more North Vietnamese soldiers were dying from malaria than from armed conflicts. The Chinese government launched a program to find new antima- larial drugs. As a result, Tu Youyou, a Chinese scientist from the Chinese Academy of Traditional Chinese Med- icine (Beijing, China), identified artemisinin as the ac- tive compound of A. annua in 1972 [1]. Its overwhelm- ing antimalarial activity was demonstrated in numerous clinical studies by Chinese and Western scientists. De- spite this success, the true potential of artemisinin was underestimated in the Western world for many years

[2]. In the meantime, the World Health Organization officially recommends artemisinin and its derivatives, such as artesunate and artemether, for the treatment of malaria, particularly as a part of combination therapies with other antimalarial drugs.

Artemisinin, artesunate, and additional derivatives are the most promising candidate compounds to ease the worldwide malaria burden. The high safety and tolerability profile of these drugs adds to their attrac- tiveness [3]. This group of compounds is also active against cancer cells and schistosomiasis

[4–10]. The fo- cus of the present review is the antiviral activity of artemisinin and artesunate.

http://cid.oxfordjournals.org/content/47/6/804.full.pdf
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