baraclude and the side

[sam0330]

I have been on baraclude for almost 2 1/2 years and lastweek i had a could and after that i start having cheast pain and also i did have inregular heart beat and i went to er and thesaid that the heart was ok . I was reading and it look like same of the side effect's on the baraclude i have them .i talk to my nurse praction and she said that it's just nothing and should continue with the pill .
I just want the opinion of a doctor what do they think about my situation .

My alt is 71  1 month ago

Before that it was 100 .

I think the baraclude is working but i worry about the side effect that can led to a lactic acidis  

ANY input on this mater i would really appriciated .

Thank you

[stef2011]

have you ever had alt below 30?if not etv is not strong enough for you

the synthoms are too many and you should check immediately if it is lactic acidosis by blood test, you might find info on lactic acidosis on hiv websites too since they have this risk too.if possible mke blood test monday too with doc visit.actually

if you have not lactic acidosis you must find the reason of these synthoms by doctor and blood tests

i suggest you switch to tenofovir which is more potent than etv and safer since no resistance, i also suggest ntz combo after you know the reason of synthoms and you get rid of them
ntz will prevent resistance in any case and lower antigens and hopefully make hbsag negative

[sam0330]

I still do not feel good after 2 visit at ER i feel really sick after i take the pill.

I have
•Fever
•Feeling tired (fatigue)
•Loss of appetite
•Nausea
•Vomiting
•Abdominal pain
•Light-colored stool (feces)
•Dark urine

I did not take it for one day and i was better but i don't know what to do . I have an appointement on monday with the liver doctor .My first doctor that was a nurse practicion told me to continue with this pill . I have been on the pill for 2 1/2 years.

Any input i would really app.

[stef2011]

nucs are for life they don't cure or affect virus, they just stop replication and liver damage, if you stop you relapse happens shortly and resistance mutation is very very probable
after resistance mutation only tnf can stop virus but we don't know how long

to stop replication 6months-1 year can be necessary, i just could stop replication within 6 months becasue made combo with ntz

[gud_gurl18]

omg...for 2 years already?are you taking it everyday continously?why does it take too long?my doc told me for only 1 year..TT

[stef2011]

if your alt is still abnormal after 2 years entecavir is not suppressing hbvdna in the liver you should have alt below 30
i suggest a combo with nitazoxanide or tenofovir first

i think sides are not related with etv and not important, fast heartbeat is nothing to worry about 99% time, as to lactic acidosis it has been seen on uncompensated cirrhosis not on nomral compensated liver function but anyway take the test, i don't know in english but something like lactate level

lab tests in italian:
Esami di laboratorio:
- incremento dell'acido lattico (> 10 mmol/l)
- acidosi severa (bicarbonato < 20 mmol/l e pH arterioso < 7,3)
- aumento di transaminasi, CPK, LDH, lipasi e amilasi
- alterazioni della coagulazione e insufficienza renale.