can I be a HBsAg -ve after treatment.

Dear all:

I am a man 45 years old, My lab result is
HBsAg, +ve
Anti-HBs, -ve
HBeAg, Non-reactive (S/CO:0.316)
Anti-HBe, Reactive  9S/CO: 0.01)
HBV-DNA,  1.24x10^5
and I will have Liver byopsi for a further check.

In this stage of my Heps B, can I be a HBsAg -ve or Anti-HBs +ve later on after treatment or need byopsi data to determine the stage of my heps B. With this lab result, now I think I will lose my overseas job.
I never have any heps B sympton in my live.

Thanks for reply.
Otan

[stef2011]

I never have any heps B sympton in my live.

hepatitis has no symptoms until you are dying of liver cancer or cirrhosis, actually a person in my town ahs no symptoms of liver cnacer until the day of death, after death they saw it was liver cancer....

HBsAg, +ve
the quantity of hbsag in iu/ml by abbott architect machine can tell.if hbsag is less than 1500iu/ml you have chances to clear on interferon+alinia, all other therapies have 0% possibility to clear and usually increase hbsag quantity on hbeag negative

[Otan]

Steff,
my HBsAg is measured as H 132.97 S/CO.
What is that in iu/ml ?

Big Thanks Steff.

[stef2011]

no that's just a very old assay that shoudln t be used anymore because totally useless for cronic (chronic) hbv carriers or screening blood......

the number s/co is reagent and has no idication at all on hbsag quantity.this assay is good only to say positive/negtive

[Otan]

Steff,

Thanks a lot.

[anoop500]

i am in merchant navy and i am suffring from hbsag+ve...
pls tel me a immediate treatment to cure pls...i have 250 iu/ml...highly reactive what to do????????????

[Otan]

Steff;
I am back again.
I have check my HBsAg  as 366.44 IU/mL and my biopsy result says I am "Hepatitis Cronic (chronic) Metavir Grade 1, Stage 1.

I have seen 2 doctors and they said:

Doctor1: No need therapy because my GPT is 51 ( ref  <50) not high give less chance to clear the HBV but to monitor SGOT and SGPT periodically. Said that, Interferron injection is quite expensive.

Doctor 2: Go with interferron for 48 weeks have injection every weeks. It cost me expensive around usd 16,000.

Which one I should follow?

Regards
Santun

[stef2011]

I have check my HBsAg  as 366.44 IU/mL

you are sooooo very lucky you can clear hbv almost 100% by:
simvastatin+vitamin d3+alinia pretreatment to improve interferon response, about 1 month should be ok, vit d3 possibly 50-70ng/ml, check serum vit d 25oh and take 10000iu daily to reach that value

than you add interferon+tenofovir to the previous combo until hbsag gets negative

for all these combo you can only get a researcher or very expert doctor to prescribe it, if you dont find one i suggest you order drugs from india where these combos  are available and low price generic drugs available

second doctor is to follow but interferon alone is too slow to clear, you must add the combos.
alinia: generic nizonide500 by lupin, available on online pahrmacies, very cheap, no sides drug allowed on 1yo babies
simvasttin, easily available every where, extremely cheap
vitamin d3 supplements, available everywhere cheap, puritans have 500iu pills very cheap, check their website

if interferon is too expensive you might try the combo without interferon and tenofovir and see if it works

[stef2011]

do not waste this chance because hbv can mutate any moment and remake hbsag high

the second doctor opinion is extremely bad doctors like that keep patients sick even when one is so lucky to have possibility to clear hbv

interferon generic is available in vietnam at lower price, in most euro countires it is free by healthcare system, if you can move residence to italy for example you just pay a little price to have healthcare coverage and interferon is free

[Otan]

Stef;

Thanks for giving me bright hope.
I am trying to find info from Penang Malaysia (Adventist Hospital) if they can provide the treatment you suggested.
FYI, I am living in Jakarta- Indonesia.

Thanks Stef...

[Otan]

Steff,
I started interferon therapy on 21 Oct 2011 (1st injection)  with my
HBSAG—366.44   IU/mL
HBV DNA—2.54 x 10^5 IU/mL
And while on therapy I took Sinvastatin, Curliv  and Becefort for one month and then took Lipanthyl, Curliv and Becefort for the other two months.
After weeks # 12,  I have my Lab result
HBSAG --  176.40  IU/mL
HBV DNA—  Virus not detected.
Do you have any comment or suggestion? Is it good progress to be cured from Heps B.?

Thanks-Otan

[stef2011]

i am so happy for you, you are going to clear 100% in such a short time, i wish i ll do the same when i start interferon soon

HBSAG --  176.40  IU/mL
this is extremely low, clearance 100%.please do not miss one injection and please make a new post about this so that others may know how hbv can be cleared so fast just following

please let's open a new post for this: hbv almost cleared 12week interferon+sim

you should check vit d3 and if less than 40ng/ml start about 5000iu daily, you can also add nizonide500 (alinia) 2g daily total (1pill with meal every 4 hrs)

[stef2011]

what about alt levels before and during therapy?

[stef2011]

we do need others to try the combo interferon+simvastatin+vitd3+tdf+alinia, which dose of simvstatin have you taken?

[stef2011]

or should say are you taking?

[Otan]

steff;

sinvastatin 10 mg

[4est]

look very good :)

what was your ALT / AST  levels before and during treatment ?

[stef2011]

he just posted, aas i thought there is a need of an alt flare whenhbvdna is und to kill infected cells and lower hbsag
i do hope my flare at alt 54 was the same with hbvdna undetactable, i will have new tests next week

Took 1st dose on 21 Oct 2011 and on 11 Jan 2012 HBV DNA not detected.  
Below is the lab history,                          

Date            13/9  20/10  21/10  11/11  16/11  9/12  15/12  6/1/12  11//1/12
                                   1st dose                                   12th dose
SGOT                    35*                          49*             63*                  67*
SGPT                    63*                          78*             89*                  90*
HBsAg     366.44  255.68                                                              176.4*
HBV DNA2.54x10^5                                                                   no detect

[stef2011]

it is also good the interferon+sim combo, until now interferon+statins was used on hcv only