Aa
A
A
Close
Blank
Avatar universal
etv is the most potent on hbsag
from boston conference 2010
https://docs.google.com/leaf?id=0B_yFgxI8KNcRNTllYzJjNjctNjg5MS00YmQ1LTliMmMtZDFjYjY4ZTA0MzVm&hl=en

etv is the most potent on hbsag as monotherapy, the 1mg dose is also the most potent as hbvdna suppression (maybe telbivudine a little more potent but not safe because of high resistance rates), etv is also the only one with hbsag seroocnversion on hbe negative

etv+tnf the most potent both for hbsag and hbvdna suppression

it is probably the best drug for alinia combo too
Cancel
7 Answers
7 Answers
Page 1 of 1
Avatar universal

of course what i posted is only for naive patients with no lam mutations present and no previous lam use since etv doesn t work in the presence of lam mutants
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
quite strange..  It would be good if it is the truth. But as far as I remember, etv has no effect on your hbsag, the first large decrease of hbsag is because of alinia.
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Avatar universal

in my case the most is due to alinia because when i lowered alinia to 1g daily hbsag jumped to 7200iu/ml immediately even if hbvdna was und, but in any case i think it is a combo synergy because if etv didn t lower hbvdna the effect on hbsag cannot be so much since new liver cells get infected all the time and more hbsag produced, at least the decrease would be slower

one thing is certain tnf makes zero hbsag seroconversions on hbe negative while etv does and this can be good news just for the alinia combo, we are talking about 3% hbsag seroconversions and 19% that get a hbsag lowering, as you said too little to even think etv alone can do something

Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
There is another research in the same meeting concluding that anti-virals have no effects on hbsag. Even if 3% is true for etv, it is still too insignificant for us to count on. I am more interested in the interferon research, which concludes that for hbeag- patients, hbsag reduction is more than hbeag+ patients. Both reductions are ~ 3.x log10. I will try to consult my doctor for a hbsag quantitative test (in US unfortunately) to see if I have chances (< 3 log10 iu/ml) to try interferon.
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Avatar universal

also interferon alone is useless on most, only 11% seroconvert, the best strategy is a combo all all the drug at the right time according to situation and when hbvdna is very low or und interferon plus alinia can make the difference

at my research center they are waiting to see if hbsag gets to 1000-1500iu/ml because interferon has high rates of seroconversion in this case, if hbsag is higher it is a waste of time
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
on hbe negative interferon can be useless if hbsag and hbvdna are high, in that case it is better start with entecavir or tenofovir and when you reach hbsag/hbvdna values tht can make a good response on interferon add-on or switch slowly interferon

hbe neg with a good interferon response had low hbsag, low hbvdna and high alt, there was already a minimum immune response henanced by interferon, if this immune response is zero interferon can de very little.the only tool to measure a minimum immune response is hbsag quantity, unfortunately there are no tools to measure immune response other than hbsag
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
In the same meeting abstracts, there is a paper emphasizes the needs of individualize the treatments for different patient. It is especially true for hbv because the cure is so immature that individualized treatments may get a portion of patients off hbv before a definite cure is found. So I think any people who are suitable for interferon should get a try since the percentage of hbsag loss is highest. It may even higher if we only count cases of hbsag < 1000 iu/ml, which if is considered to be the criterion for possible hbsag loss.
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Your Answer
Avatar universal
Answer
Know how to answer? Tap here to leave your answer...
Answer
Submit Answer
A
A
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis B Community Resources
RSS Expert Activity
233488 tn?1310696703
Blank
Marathon Running Done Over Many Yea...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
233488 tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
748543 tn?1443740527
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank
Top Hepatitis Answerers
Avatar m tn
Blank
stef2011
Italy
Avatar m tn
Blank
sorte
Poland
Avatar m tn
Blank
Aduiski
Other
Avatar m tn
Blank
StephenCastlecrag
Australia
Avatar m tn
Blank
mike9111
MI
Avatar f tn
Blank
Royal36