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hbeag +
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hbeag +

any idea how to sero convert hbe ag or hepatitis b antigen?...
im a hbeag positive..thats why im cant onboard a vessel as seafarer because of this....my physician told me to clear the hbeag or become hbe ag negative....

my question now is....is there any remedy or cure to be hbeag negative....?
thanks!
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Avatar_m_tn
it is an old view that making hbeag negative is good, when it happens out of therapy it is always a mutation of the hbv virus to precore or bcp for genotype D and a worsened state of infection with time.other genotypes might have lower rates of mutation

the only good thing is:
tenofovir for 3 years or more (in case of hbeag positive hbv is cleared in 16% cases already)

if hbsag is not cleared by 3 years of tenofovir (hbsag cleared means hbv cleared):
add on peginterferon to tenofovir for another 2 years

in the end most clear hbsag (hbv) and develop hbsab antibodies, few patients reach a very low hbsag quantity which determine an inactive state of infection which is slowly cleared by the years of by tenofovir monotherapy

total time to cure hbv by sequential treatment 4-5 years, 50% clears in 4 years the rest of patients have very low hbsag levels and might clear in the following years
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Avatar_m_tn
Its good to hear that. I'm hbsag + and with tenofovir it got reduced to a great amount in 6 months but the problem is hbeag has become + which was earlier  -. Wat should i do?
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Avatar_m_tn
Its good to hear that. I'm hbsag + and with tenofovir it got reduced to a great amount in 6 months

not 6 months, 3 to 5 years on 50% of treated patients only.in case of no hbsag decrease at all peginterferon can be tried and see if hbsag goes down by 12 weeks of combo
only those with hbsag less than 1000iu/ml have high chances to clear on pegintf add on to tdf after 3 to 5 years of tdf mono

so it is a slow process.you can check your hbsag quantity in iu/ml, only architect and elecsys to check quant in iu/ml so check tha lab has this machine for quant before doing the test.hbv genotype is helpful too

after we have these tests we know if tdf or peg is the best choice
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Avatar_m_tn
This has been really helpful and very eye opening, I really appreciate you sharing your experience. I would like to know
I am hbsag positive hbeag negative  anti hbs  positve,; alt   11   ast 18

hbv quantitative befor viread treatment it was 8505 iu/ml

after 6 months  with viread it became 58650.3iu/ml (abbott m200)

hbv DNA it  inwas 1100 know undetected.. what do you think of it? Should I continue with treatment? I would appreciate it if you would explain to me a bit.Thank very much.
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