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hbeag postive
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hbeag postive

hi to all... i have a concern about hepatitis b.
has everyone know how to convert from hbeag reactive to nonreactive?...
is there a medicine/therapy ?

9 Comments Post a Comment
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Avatar_m_tn
We are all concerned about Hepatitis B here. There is no cure for HepB at the moment but there are very effective treatments to control the disease from progressing to serious liver disease.
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Avatar_m_tn
can you mention what are those effective treatments sir?
thank you........
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Avatar_m_tn
First of all, not all hbvers require immediate treatment, sometimes it is not necessary to treat but simply to monitor. If treatment is needed, the first choice is Pegylated Interferon, a 48 week course of once weekly injection. The other two first-line drugs are Tenofovir and Entecavir, both a daily pill of at least several years duration treatment. For the more adventurous, treatment will consist of combination treatment with PEG IFN with TDF or ETV in various sequence, add-on, mono/combo combinations.
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Avatar_m_tn
Hahahaha "for the more adventurous" you made this disease so light with that :D

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Avatar_m_tn
What is adventurous today, maybe passe to-morrow. I once saw a TV program of a surgeon doing a lung transplant. I think there were only two persons, including the surgeon, excluding the patient, in the theater.
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Avatar_m_tn
Hi StephenCastlecrag
Sir
can entecavir convert the E antigen or hbeag from reactive to non reactive?because tenofovir is not available in the philippines,,
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Avatar_m_tn
Drugs like Entecavir and Tenofovir will inhibit the replication of virus, hence reduce viral load and this should normalize ALT, reducing inflammation and prevent fibrosis. This is the most important reason for taking Entecavir/Tenovir. Certainly, most patients who take Entecavir will also seroconvert their eAg after a period of time of treatment. This may serve as an endpoint of treatment after 3 consecutive test results of undetectable hbvdna.

As to whether Entecavir directly cause HBeAg seroconversion, I am not so sure (just my personal view). I feel there are other host and viral factors at play.
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Avatar_m_tn
if ever i take entecavir and seroconvert my hbeag?can i stop taking this antiviral right away?
is there a chance of getting resistance with the drug and reactivation flare if stop taking it?...
what is the correct step when stopping it?

thank you..
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Avatar_m_tn
You asked very good questions. I don't know the answers. Generally, stopping can be considered after 3 consecutive (6 months apart?) tests showing undetectable viral load. I must add, researchers from Taiwan support stopping with close monitoring after stopping, but European researchers said they don't stop. So there is no uniform agreement, may be more research with HBsAg level as an indicator may identify a valid stopping rule.
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