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hbsag down 72% in vitro by a super old, stupid, inexpensive antifungal ...
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hbsag down 72% in vitro by a super old, stupid, inexpensive antifungal drug

there are so many compounds active lowering hbsag, the bad is researchers find them but we have never seen any additional research on anything against hbsag.....they probably want hbsag to remain......

anyway here is the link to the study:
http://onlinelibrary.wiley.com/doi/10.1002/jmv.1890160308/abstract

Abstract
The effects of amphotericin B, ketoconazole, and adenine arabinoside on production of hepatitis B surface antigen (HBsAg) particles by the human hepatoma cell line PLC/PRF/5 were examined. In addition, the effects of these drugs on cellular protein synthesis were determined. These drugs caused a dose-dependent decrease in HBsAg production that was paralleled by a decrease in cellular protein synthesis. Ketoconazole was the most active of these drugs and the most specific, causing a 72% reduction in HBsAg production with only a 38% reduction in protein synthesis. These data suggest that further studies evaluating ketoconazole for the treatment of chronic hepatitis B virus infection in animals are warranted.

attention:
ketoconazole tablets may have liver toxicity (as almost all drugs) so liver function must be controlled at least weekly (SGGT, alkaline phosphatase, alt/ast and bilirubin)
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