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hbsag

what is the reason that sometimes the PCR for hbvdna is zero and the hbsag is positive by ELISA  and what is the explanation from lab perspective thank you.
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Avatar universal
Thank you for your post. It’s clear you have come here to help others and that is a very kind and selfless gesture. Please provide before and after blood tests results and the protocol used to clear/treat HBV. Your testimony is valuable but would be more so with the tests results and what was used. Also, clearing the virus completely would be excellent however it is still valuable to know if the treatment at least reduced liver enzymes to healthy levels and or reduced viral load.  A permanent cure is most ideal but to make a positive impact towards heath is also quite valuable.

Thanks again!
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Avatar universal
i am sorry but even if we ask you to post tests results this is useless, in cameroon you don t even have the tests to see hbv clearing and see if it was immune system naturally ir whatever else
so you cannot even think to prove what you are saying is true or know if the dr is just making a fool of you, without all hbv tests there is just no way but to make a guess
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Avatar universal
infection of hbv virus is due to the presence of cccdna in infected cells, cccdna is the virus template which produces everything, hbsag, hbeag, hbcag, hbvdna and so on, so you can understand from this that hbvdna have no meaning in terms of hbv infection itself.

hbvdna can only measure the replication of the virus and when the virus replicates in high numbers the immune system kills the cells producing hbvdna and makes liver damage.
the sensibility of hbvdna is poor and hbvdna zero means low replication, it doesn t mean no replication and can be used as a measure of activity of some hbv drugs.
so hbvdna has no meaning at all in terms of number of infected cells and hbv infection, hbvdna can be zero and alt normal and at the same time cccdna/hbsag can be increasing infecting new cells

so in the end the only thing that has a meaning in terms of infection is hbsag being negative which is correlated with low cccdna, low number of infected cells and immune control of the infection
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