hbseg positive to negative

[March06]

now we know hbseg pos to hbseg negative is not good. i think if ARC520 becames successfull  it will be approved for hbseg posive patient. can tenofovir treatment seroconverts hbseg  to negative? how many percent it seroconverts to hbseg neg? at this point i dont want to be hbseag negative .

[stef2011]

most hbeag negative have the precore mutations and others...this is what makes hbsag loss difficult on hbeag neg, but there is also a portion with hbeag neg and no mutations, still wild type

[StephenCastlecrag]

I have to disagree completely with your comments.
e-seroconversion is a significant milestone in a person's natural history of HBV. For those who e-seroconvert naturally, it is the beginning of an inactive phase without the need for medication and a chance to s-seroconvert. For those on treatment, NUC or Interferon, with positive HBeAg, it marks the beginning of a consolidation period after which the patients may stop medication and be in an inactive phase.

For all those in the inactive phase, the disease must be monitored regularly so that if re-activation occurs, that is hbvdna and ALT rise again, treatment should be considered to avoid the development HBeAg negative chronic Hepatitis B.

[March06]

sorry for the duplication ......somebody delete this one!