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Avatar universal

hbv and alinia=very very good news

good article about first hbv patients trying alinia over one year in mono tx and 1 patient in combo with adefovir

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670405/

mono-tx with the highest hbe and hbsag loss, no resistance, no sides.i think we should start to use it very soon in combo with antivirals since it looks the best medicine for hbv by far.
at the moment we don't have a tx with no sides and no resistance which leads to hbsag loss in a very high percentage and according to this article it is synergistic with nucs and interferon

alinia is already on the market FDA-approved treatment for Cryptosporidium
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Avatar universal
please dont rescue posts so old, anything from 2010-2011 has changed...and alinia didn t work at all, at least on me
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Avatar universal
So it does't make sense to take alinia if I'm not on any therapy ? Also I don't know yet my HBsAg quantity
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Avatar universal
Any more news on alinia?
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Avatar universal

alinia worked partially to decrease hbsag first few months but after 4-6 weeks hbsag returned to baseline levels.it did not work both monotherapy or combination

nobody tried with intf except 1 member here. for now we cannot say it works at all it may just boost intf response a little
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Avatar universal
  anybdy want alinia..mail mee..dr.yasir
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Avatar universal
   if anybody want alinia...txt me
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Avatar universal
So how do people do with Alinia?
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Avatar universal
Recently my HBV viral load increase to 500,000 copies/ml.

some are trying mono but i think with high viral loads it can work only with interferon, entecavir or tenofovir combo
it acts on immune system and lowers hbsag not hbvdna, so mono might take years to get hbvdna und, my sister is using it mono and close to 6 months, i will post her results in october.
it works on hbe negative, many asian hbe pos are trying it too but results are very very slow

hepatitis technologies anti-fibrotic protocols
never heard of these

Can I take Alinia with their Nutraceutical Liver support system?
don t know

I am only 155lb's do I need to dose at 2g/day or I could I get by with 1.5g/day?
you have to try doses and see which one lowers hbsag, higher bmi has lower response on ntz

Should I really take it with a high fat meal?
absorption is about 50% more and half-life in the blood increases but i don t use fat meal and just take ntz every 6 hours (at 7 hrs no drug effective anymore)

better combo with antiviral, entecavir has no sides if you have no lam or adv use and checked you have no resistance mutations it is the best combo drug.if you don t have these tests available tenofovir is safer for resistance and it has sides on less than 1%.
interferon has many sides so i'd not choose this


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Avatar universal
Hi Stefano,

I have been using hepatitis technologies anti-fibrotic protocols for over 4 years with great success. Recently my HBV viral load increase to 500,000 copies/ml.
Can I take Alinia with their Nutraceutical Liver support system?
I am only 155lb's do I need to dose at 2g/day or I could I get by with 1.5g/day?
Should I really take it with a high fat meal?
Can I take only the Alinia instead of a anti-viral as I find the side effects greatly decrease my quality of life.
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Avatar universal
if you reached hbvdna und on sebvivo within 6 month keep this monotherapy and check hbsag quantity, if it doesn't decrease switch to another antiviral like etv or tdf

as to the combo the problem is we have no data on combo sebvivo+alinia, probably because sebvivo is not a potent antiviral so there is no need to check with this one and since this has resistant mutation concerns i would never suggest a combo with this one

the only situation for a combo with alinia would be to switch to tenofovir or entecavir.if you don't see any decrease in hbsag talk to your doctor about changing antiviral to tenofovir or entecavir.also tell your doctor that recent data from vienna congress says that hbe seroconversion is not durable with antivirals and that therapy should be continued until hbsag seroconversion, in this situation tenofovir or entecavir are better option
the only case to keep using sebvivo would be a continuous decrease of hbsag and hbvdna und
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Avatar universal
Hi Stefano

Thank you so much.

I am HBeAg -ve before the treatment also based on the viral count(2500IU/ML and SGPT 76) doctor prescribed me Sebivo.  
So it is better to start the alinia once the HbsAg level drops to below 500 iu/ml and not with the sebivo combo.  Correct me if my understanding is wrong.

Thanks for the help.
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Avatar universal

as to hbsag quantity make blood test with iu/ml unit, other tests are not accurate for quantity although i know that 200-300s/n is a low quantity usually found on inactive carriers

when hbsag reaches 10iu/ml seroconversion is very almost certain at about 90%, on hbe negative hbsag less than 500iu/ml is a very good baseline condition for seroconversion
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Avatar universal

according to first clinical cases it takes about 1-2 years to clear on monotherapy on a high rate, combo with antiviral will give higher rates

researchers suggested use of entecavir or tenofovir which are more potent than sebvivo (telbivudine), also consider that a positive hbvdna on telbivudine for more than 6 months is very dangerous for resistance mutations.
the good part of sebvivo is that it has effect on hbsag too, what is your condition hbe pos or negative?

i cannot sugest alinia combo with telbivudine because there has been no vitro research about sinergy, if you don't see hbsag lowering in 6-12 months with hbvdna complitely und i would switch to tenofovir combo with alinia, a high hsag baseline is a good condition for hbe positive tenofovir therapy on genotypes A and D

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Avatar universal
Hello All
Below is my HBSAG reading i am using Sebivo right now and as per my doctor he will tell me on June whether I can stop taking sebivo or not.  
My latest(Jan-2010) HBV DNA value <3IU/ml.  SGPT 72.  

Is alinia is useful for me to make HBSAG -ve?
Thank you

(April-2010 Report)
HEPATITIS B SURFACE ANTIGEN REACTIVE NON REACTIVE
H 1375 Ref. ranges for
Electrochemiluminescence
or = 1.00 (Reactive)
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948882 tn?1270553807
Nice information !!

You are doing good job on this forum, as some old timers are taking it is easy :)
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Avatar universal
pump
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1024307 tn?1291998486
Thank you,Stefano.
If you hear anything else about it,please keep us posted.:)
Take care-April
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Avatar universal

the website is not updated and hbv trial is the same from 2006

trials are very slow because romarke is not a big pharma company (see HR post, plus i don't think they have a lot of profit on alinia).
they are now making a different tablet with slow release and higher dosage for hcv and hbv, i think they want to make the trial of this new tablet after they have tried it on hcv

the dosage until now has been 500mg twice daily (1000mg), new release tablet is about 1350mg twice daily, the new tablet is also focused on antiviral potency rather than antibacterial potency.
i don't think they produce for the whole world but give licence for other companies, for example hcv tablet will be produced by another company in japan.

i also think there might be a lot of off label treatments around the world like it happened for tenofovir, FDA approved it on 2009 but many has used it since early 2002/2004, for alinia it can be even more because it has no sides

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1024307 tn?1291998486
Hello,just a one note about the very first first article.
It says that a formal phase II study is being planned for 2009. It's already 2010. I've checked the clinical trials and there isn't anything right now going on in this matter. Has Romark stopped with these promising trials? Do you know,Stefano, or anybody else,anything about it?
I  live in Canada. Just out of curiosity I had called yesterday my regular pharmacy to enquire about Alinia. They don't have it in stock but could order it for me anytime. Of course I would need a prescription. I double checked if it's the original or generic. It's the original. But the pharmacist told me that there are many different kinds (dosage). What dosage do we know,is the right dosage for HBS? My husband is on Viread.I wouldn't use Alinia without the doctors approval but it's good know all the other options,for the future.:) Kind regards-April.
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Avatar universal

http://www.merlonipharma.ch/

this is a real pharmacy, i have bought medicine online and in their shop, it is in Switzerland (on italian borders) and products are 100% safe, i just emailed to check they have alinia and generics

prices are almost the same or little cheaper than other pharmacies (i compare to italian ones which are usually expensive) but you are 100% sure you are buying Alinia® (nitazoxanide) compound

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Avatar universal
by the way i also checked hbsag seroconvertion rates with all antivirals, adefovir in monotx as almost 0% chances of seroconvertion (natural seroconvertion is 1-2% per year), so the best combo chances with alinia are probably with 3, 2 and 1, theoretically alinia is also the best combo the prevent resistance since it works against all resistant strains and has no resistance

1 Entecavir           5,1%
2 tenofovir              6%
3 tenofovir+ftc   10,3% per year (early data on hiv coinfected patients)
4 adefovir              1,9%
5 LAM                     0%
6 seroconvertion and loss hbsag 1-2% per year naturally
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Avatar universal
i have found other info

treatment of a patient refractory to lam in 2006
http://www.hivandhepatitis.com/2006icr/ddw/docs/061606_d.html

in july 2008 there are reports that talk about alinia+entecavir and alinia vs entecair trial, any data from this would be very very interesting and if available i would start alinia now (page 14):
http://www.treatmentactiongroup.org/assets/0/16/42/196/198/bfb084dd-e770-4319-8df1-a0efbea7a08d.pdf

i have sent an email to romark and asked if entecavir and alinia work in synergism or at least if they have in vitro data to exclude interference, i do hope they can give some data already.

point of view of HR on romark company and if their data is reliabe or too optimistic like big pharma makes usually (these posts are from jan 2008 so it considers only for hcv tx):
http://www.medhelp.org/user_journals/show/2391



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1024307 tn?1291998486
Hi Stefano. Thank you for valuable information.-April
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Avatar universal

thanks for the link, it is very useful info

i found canadian pharmacy too the other day and that's the only one i would trust becuase you have an address and a phone number, so we can check if it is a real licenced pharmacy.
i wouldn't trust any other source becuase it is too dangerous to buy medicines from india/china/3d world countries online even if nitazoxanide is a very easy chemical.

i guess the best way is to buy alinia from canadian pharmacy and then check with romark if it is their product by serial numbers on medincine box.

in any case i wouldn't mix antivirals other than adefovir until we have some trials that confirms alinia works synergistically also with entecavir/tenofovir.
it would also be very good if anybody could get in touch directly with romark in tampa and see if they have more info on use for hbv, the article is from 2008 and pubblished april 2009 so i guess they have some more info by now.
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