hbv lowers bone density, vit D deficency maybe the cause

http://www.hbvadvocate.org/news/HBJ8.5.htm

HBV Infection Appears to Contribute to Bone Loss
An international team of investigators looked into risk of bone loss in 250 hepatitis B patients who were evaluated before enrolling in the above-mentioned tenofovir clinical trials. They screened the patients’ bone density because tenofovir has been linked to bone loss.

Some had previously been treated with other antivirals. The researchers found many of the patients already had reduced bone mineral density, 6 had osteopenia, or low bone density, while 4 had more severe osteoporosis before treatment began.

Past antiviral treatment appeared to have had no impact on bone density, they noted. They did find that males and Asians have greater reductions in bone mineral density compared to females and non-Asians.

“Our data demonstrate a higher prevalence of baseline bone disease among patients with chronic HBV,” they concluded. “Duration of chronic HBV but not duration of treatment appears to [have an] impact [on] bone mineral density.”

[stef2011]

the study doesn t check vit D but since all cronic (chronic) hbv carriers have vit D deficency this is probably the cause.
i think vit D is owered by the virus to block macrophage activation and block immune system responsee together with other strategies...nagalase is the other suspect of blocking immune response

gcmaf might be the answer