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hbv
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hbv

Dear Dr. i have been taking entacavir since last two years. since last 10 months hbv dna is coming <20. But hbeag level is 3.7 and hbsag is 250. Which drug can be added to help it out
6 Comments Post a Comment
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Avatar_m_tn
entecavir has no effect on hbsag, to lower hbsag you must add on interferon to entecavir

hbsag is not 250iu/ml but higher than 250iu/ml, the lab which did the test fraud you because they did not diluite your sample to check exact level of hbsag

99% of hbv carriers have hbsag higher than 250iu/ml, there is no need to test to know that.....
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Avatar_m_tn
Dear Sir, Thank you for your valuable reply. will this also lower the level of hbeag which is 3.7 at present?
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Avatar_m_tn
You don't know if you seroconvert until you're on IFN treatment.
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Avatar_m_tn
Dear ,
do you suggest any laboratory test before adding interferon? and kindly suggest the doze of interferon
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Avatar_m_tn
You need to be monitored by a hepatologist while on IFN treatment.
Its not a do it yourself treatment.
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Avatar_m_tn

you must get hbsag quantity iniu/ml (the exact number with diluition) before you start intf and then check at 12 weeks and 24 weeks, so it is possible to know if intf is working or not.
if there is no hbsag decrease by 24 weeks you are an intf non responder and it is best to stop intf and keep entecavir monotherapy while if you experience any hbsag decrease by 24 weeks you can be fast or slow responder and it is best to keep etv+intf

once you see that hbsag goes down continuatively under intf+etv you better keep this combo for 96weeks until hbsag goes und and hbsab appear to more than 10miu/ml

definitely a good liver specialist needed to monitor all this
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