you must get hbsag quantity iniu/ml (the exact number with diluition) before you start intf and then check at 12 weeks and 24 weeks, so it is possible to know if intf is working or not.
if there is no hbsag decrease by 24 weeks you are an intf non responder and it is best to stop intf and keep entecavir monotherapy while if you experience any hbsag decrease by 24 weeks you can be fast or slow responder and it is best to keep etv+intf
once you see that hbsag goes down continuatively under intf+etv you better keep this combo for 96weeks until hbsag goes und and hbsab appear to more than 10miu/ml
definitely a good liver specialist needed to monitor all this
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