this post is from a lot of time ago but this is a good example, to explain latest studies from brunetto researcher in italy and maybe some other researchers around the world:
hbsag values can help predict seroconversion with interferon (also with nucs but more studies are needed) when lower than 320 S/N (1000-1500iu/ml, values that are usually for inactive carriers).
beso2 is clearing infection by hbsab antibody, if he has been so lucky hbsag reached even lower values and seroconverted by hbsab antibody, i think a good moment for alinia to help.
the only meds that lowers hbsag are interferon and alinia (off label), so if you are having a very low hbsag quantity with active disease it is better not to start any antiviral because they do not lower hbsag and maybe they can even increase it by viral mutations (i don't mean viral mutations that confers resistance) which can happen with antivirals
this is very important, for example i have low hbsag and have been started with etv, but maybe interferon was better for me since this low hbsag baseline
this hbsag quantification test was not performed by my first doctor and i think a lot of doctors don't check it before starting tx, this is very imprtant to choose tx because nucs have very low seroconversion rates while interferon about 30% in a couple of years and this low hbsag have very high probability to be in this 30%
forgot the most important thing of hbsag quantity, it is useful to check response of interferon or antivirals because hbsag reflects cccdna in the liver cells.
so once you have achieved hbvdna und it is very important to see hbsag quantity and of course when it gets lower it means cccdna is getting lower and tx is working
for hbe positive with hbvdna und during tx it is possible to check hbe quantity and hbs quantity to predict seroconversion to hbeab but you should check for research on this matter since no guidelines are issued for this and most docotors are not aware of this
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