Aa
hep b
i have compensated cirhosis right now, i am hbsag positive and delta virus is active too tough not a very high viral load
doctor told me take tenofovir silliver urso to manage all other conditions too after 9 days will go for my ALT test
will i be able to regress it? please help me out am i taking right medicines?
i am new to this forum hope you guys respond to me
doctor told me take tenofovir silliver urso to manage all other conditions too after 9 days will go for my ALT test
will i be able to regress it? please help me out am i taking right medicines?
i am new to this forum hope you guys respond to me
no problem. I was more depressed than you in 6 months ago.
I learned that I am a patient one month ago before my wedding. you cannot imagine my psychology.
Do not worry You will become normal day by day.
I learned that I am a patient one month ago before my wedding. you cannot imagine my psychology.
Do not worry You will become normal day by day.
Yes, you should be F4. What if you are not F4 according to Fibroscan, like in my case.
So, please confirm that you are F4 with fibroscan, and follow your cirhossis regression with fibroscan in every 6 months...
So, please confirm that you are F4 with fibroscan, and follow your cirhossis regression with fibroscan in every 6 months...
Actually, it is not correlate with HBV DNA. Now my HBV DNA is 450 but qHBSAG is over 52000 (that means very high). So, you may have little qHBSAG. You should find a way to do it. Ask to the forum to learn where in Pakistan.
And also it is very important to learn your Fibroscan result. This is a must for you. Listen... According to my biopsy result, my doctor told me that I am in the just previous stage of becoming cirrhosis which is F3 over F4 (F4 means chirosis).
And I learned that there is a machine to measure the stiffness of the liver, which is called fibroscan. There is one in Istanbul. Then I go to Istanbul for fibroscan. Fibroscan seems like ultrasound. The result of fibroscan is that I am F1 over F4. That means my liver is really healthy.
So, you should learn your Fibroscan result. And check it in every 6 months to learn regression or progression. That will give you the answer of how is your treatment going. This is must for you.
And also it is very important to learn your Fibroscan result. This is a must for you. Listen... According to my biopsy result, my doctor told me that I am in the just previous stage of becoming cirrhosis which is F3 over F4 (F4 means chirosis).
And I learned that there is a machine to measure the stiffness of the liver, which is called fibroscan. There is one in Istanbul. Then I go to Istanbul for fibroscan. Fibroscan seems like ultrasound. The result of fibroscan is that I am F1 over F4. That means my liver is really healthy.
So, you should learn your Fibroscan result. And check it in every 6 months to learn regression or progression. That will give you the answer of how is your treatment going. This is must for you.
inchallah all members get cured,as safi say all of us should be optimist
i think one of members ali is from pakistan you can ask him for lab;
What is obv?
i think one of members ali is from pakistan you can ask him for lab;
What is obv?
i live in Pakistan i am not sure if we have it here or not, but i am sure i must have it high too obv because my hbv dna is high tooo
It is a simple test. But you cannot find it in everywhere. For example, here in Turkey, only one lab do this test by 200 USD. You should ask your hospital to help you. The name of the test Quantitative HBSAG (qHBSAG). Do not mix with Qualitative HBSAG (you already did before, the Elisa one)
This test gives the real number of virus inside you. HBV DNA is just a part of the virus and easily suppressible. My HBV DNA was 557 000 000 (557million) in 6 months ago. Now it is only 450. So it is not that much important. If your qHBSAG is less than 5000 IU/ml, it means you can totally get rid of this illness.
Unfortunetly, mine is over 52 000 IU/ml (the test cannot count over 52000).
This test gives the real number of virus inside you. HBV DNA is just a part of the virus and easily suppressible. My HBV DNA was 557 000 000 (557million) in 6 months ago. Now it is only 450. So it is not that much important. If your qHBSAG is less than 5000 IU/ml, it means you can totally get rid of this illness.
Unfortunetly, mine is over 52 000 IU/ml (the test cannot count over 52000).
HBSAG (elisa) is useless. It does not mean 456 or 5433 or 1085 or what ever. There is no unit. The important one is qHBSAG (which has IU/ml unit.)
my doctor told me that three year tenefovir treatment will regress my cirhosis
also what does it mean hbs ag 1085 (ELISA)
also what does it mean hbs ag 1085 (ELISA)
PLUS, We have a great hope. Read the link below
http://replicor.com
http://replicor.com/antiviral-technologies/hepatitis-d/
http://replicor.com
http://replicor.com/antiviral-technologies/hepatitis-d/
READ THIS RESEARCH AND GIVE UP FEELING DEPRESSED
FACTORS ASSOCIATED WITH REGRESSION OF CIRRHOSIS IN PATIENTS WITH CHORNIC HEPATITIS B (CHB) INFECTION TREATED WITH TENOFOVIR DISOPROXIL FUMARATE (TDF)
Speaker: Nezam Afdhal
Author: N. Afdhal1*, M. Buti2, S. Fung3, E. Gane4, J. Flaherty5, E. Martins5, N. Bekele5, J. Bornstein5, P. Marcellin6
Affiliation: 1Harvard Medical School, Boston, MA, USA, 2Servei de Medicina Interna-Hepatologia, Vall d'Hebron Hospital General, Barcelona, Spain, 3Univeristy of Toronto, Toronto, ON, Canada, 4Auckland City Hospital, Auckland, New Zealand, 5Gilead Sciences, Foster City, CA, USA, 6Hopital Beaujon, Clichy, France. ****@****
Regression of fibrosis is an important clinical outcome for patients with CHB who achieve long term viral suppression with nucleos(t)ide therapy. It has been previously reported that up to 5 years of TDF therapy results in a regression of cirrhosis in 74% of patients. The clinical and pathophysiologic differences between those that had reversal and those that did not has not been described.
Methods: A retrospective analysis was conducted on 96 cirrhotic patients (Ishak fibrosis stage ≥ 5) who had liver biopsies at baseline and at year 5 in 2 studies that compared the safety and efficacy of TDF to adefovir for 48 weeks in HBeAg negative (Study 0102) and HBeAg positive (Study 0103) patients, followed by open-label TDF treatment for an additional 7 years.
Results: 96 patients with cirrhosis at baseline had follow-up biopsies at year 5. 71 of the 96 (74%) were no longer cirrhotic (Ishak fibrosis stage ≤ 4). Among the different baseline covariates assessed, elevated body weight (87.4 kg vs. 76.8 kg, p=0.013) and body mass index (BMI) (29.0 kg/m2 vs 25.7 kg/m2, p< 0.001) were the only variables that were significantly correlated with persistent cirrhosis. Age, gender, race, viral genotype, inflammation, platelet count, albumin, ALT, and DNA and HBsAg titers did not correlate. There was a trend showing that patients with a shorter time since diagnosis and those with Ishak fibrosis stage 5 were more likely regress than those with longer duration of infection and Ishak stage 6 fibrosis. Subjects who were no longer cirrhotic were more likely than those with persistent cirrhosis to have a normal ALT at year 5, but no other differences were noted in outcomes for those that resolved cirrhosis vs. those that did not. Both groups had similar increases in platelet counts and albumin levels, similar rates of HBeAg loss, viral suppression, and HCC rates. No patient in either group had ascites, variceal bleeding or hepatic encephalopathy.
Conclusion: TDF therapy results in a high rate of cirrhosis reversal. Persistence of cirrhosis is most likely when risk factors for a 2nd disease such as obesity induced liver disease co-exists.
FACTORS ASSOCIATED WITH REGRESSION OF CIRRHOSIS IN PATIENTS WITH CHORNIC HEPATITIS B (CHB) INFECTION TREATED WITH TENOFOVIR DISOPROXIL FUMARATE (TDF)
Speaker: Nezam Afdhal
Author: N. Afdhal1*, M. Buti2, S. Fung3, E. Gane4, J. Flaherty5, E. Martins5, N. Bekele5, J. Bornstein5, P. Marcellin6
Affiliation: 1Harvard Medical School, Boston, MA, USA, 2Servei de Medicina Interna-Hepatologia, Vall d'Hebron Hospital General, Barcelona, Spain, 3Univeristy of Toronto, Toronto, ON, Canada, 4Auckland City Hospital, Auckland, New Zealand, 5Gilead Sciences, Foster City, CA, USA, 6Hopital Beaujon, Clichy, France. ****@****
Regression of fibrosis is an important clinical outcome for patients with CHB who achieve long term viral suppression with nucleos(t)ide therapy. It has been previously reported that up to 5 years of TDF therapy results in a regression of cirrhosis in 74% of patients. The clinical and pathophysiologic differences between those that had reversal and those that did not has not been described.
Methods: A retrospective analysis was conducted on 96 cirrhotic patients (Ishak fibrosis stage ≥ 5) who had liver biopsies at baseline and at year 5 in 2 studies that compared the safety and efficacy of TDF to adefovir for 48 weeks in HBeAg negative (Study 0102) and HBeAg positive (Study 0103) patients, followed by open-label TDF treatment for an additional 7 years.
Results: 96 patients with cirrhosis at baseline had follow-up biopsies at year 5. 71 of the 96 (74%) were no longer cirrhotic (Ishak fibrosis stage ≤ 4). Among the different baseline covariates assessed, elevated body weight (87.4 kg vs. 76.8 kg, p=0.013) and body mass index (BMI) (29.0 kg/m2 vs 25.7 kg/m2, p< 0.001) were the only variables that were significantly correlated with persistent cirrhosis. Age, gender, race, viral genotype, inflammation, platelet count, albumin, ALT, and DNA and HBsAg titers did not correlate. There was a trend showing that patients with a shorter time since diagnosis and those with Ishak fibrosis stage 5 were more likely regress than those with longer duration of infection and Ishak stage 6 fibrosis. Subjects who were no longer cirrhotic were more likely than those with persistent cirrhosis to have a normal ALT at year 5, but no other differences were noted in outcomes for those that resolved cirrhosis vs. those that did not. Both groups had similar increases in platelet counts and albumin levels, similar rates of HBeAg loss, viral suppression, and HCC rates. No patient in either group had ascites, variceal bleeding or hepatic encephalopathy.
Conclusion: TDF therapy results in a high rate of cirrhosis reversal. Persistence of cirrhosis is most likely when risk factors for a 2nd disease such as obesity induced liver disease co-exists.
You should know that your cirrhosis will CERTAINLY REGRESS if you,
1. give up feeling depressed
2. try to be positive (I am serious.)
3. pry for yourself and all patients
4. take your pill at the same time in every day.
5. eat healthy (vegetables and fruits)
6. live healthy (little exercise, good sleep, no alcohol, o smoke, etc.)
7. try to be familiar with these concepts and be able to interpret your test results (qHBSAG, HBEAG, HBV DNA, ALT, AST, FIBROSCAN, BIOPSY, AFP, URINE, ANTI HBV)
9. Follow this forum and share your test result regular.
10. Do not forget you are lucky. You have a treatment option. Liver is the most powerful part of the body and it renew itself totally if you eleminate the cause of disease. You would have cancer or aids or even worse. So again number 1 and number 2.
1. give up feeling depressed
2. try to be positive (I am serious.)
3. pry for yourself and all patients
4. take your pill at the same time in every day.
5. eat healthy (vegetables and fruits)
6. live healthy (little exercise, good sleep, no alcohol, o smoke, etc.)
7. try to be familiar with these concepts and be able to interpret your test results (qHBSAG, HBEAG, HBV DNA, ALT, AST, FIBROSCAN, BIOPSY, AFP, URINE, ANTI HBV)
9. Follow this forum and share your test result regular.
10. Do not forget you are lucky. You have a treatment option. Liver is the most powerful part of the body and it renew itself totally if you eleminate the cause of disease. You would have cancer or aids or even worse. So again number 1 and number 2.
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