Today i got hbsag quantitative test (abbot arcitect)
QHBSAG 128 iu/ml
QHBSAG 320 iu/ml
my previous test was
Hbsag confirmation test positive.
Antihbc total Reactive (CMIA) 12.86
antihbc IgM non reactive.(CMIA) 0.5
Antihbs Non Reactive.(CMIA) 0.81miu/ml
Hbeag Non Reactive(CMIA) 0.36
Hbv Dna Undetechable(PCR) <3.6 iu/ml
what can i do for clear hbv.
Should i watch hbsag quantity.
I am not taking any medication now.
Whats ur opinion.
Hi, your HBsAg levels are persisting. Hepatitis B surface antigen (HBsAg) level of less than 1 s/c is considered negative, while a level more than 5 s/c is considered positive.As HepB Core IgM values are low, it implies the IgG values are high. So, to sum up HBsAg is reactive and HBsAb negative, HepB Core IgG is positive so you are in chronic state. But as the viral load is low you may not need any therapy now. Keep monitoring the values and hope for improvement. Good luck. Regards.
if you want to clear in few weeks to few months the only way is peginterferon, some members used off label simvastatin and cleared hbsag in less than 16weeks
otherwise hbsag will keep going down but it will take years, but in the meantime you can have hbsag mutations in the a determinant region and lose the opportunity to lose hbsag, this possibility is not very high but possible
another uncommon scenario is occult hbv and according to the mutation type:
hbsag will accumulate inside liver cells making damage and very high liver cancer risk despite hbsag negative, hbvdna undetectable, normal ast-alt. antivirals have no effect on occult hbv
so best thing is fasten the process of hbsag clearance if you want to clear hbv as soon as possible.if you want to run a low risk of relapse by hbsag mutation or low risk occult hbv go on hoping hbsag will go down faster
hbv is made of mutants, there is not a single hbv type as it replicates it makes error and changes its structure.so hbv is made of many populations of viruses, some mutants will disappear because not fit and others will survive
this continuous mutation as the virus replicates is to escape immune system or drugs and some mutations are very dangerous while most are not
tenofovir has no resistance mutations while all other antivirals have, peginterferon mono has also reported hbsag escape mutants while peginterferon plus tenofovir or entecavir probably dont
please don t ask more about this because complicated, long to explain and not so important
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