interesting report about clevudine

[stef2011]

http://archive.mail-list.com/hbv_research/message/20110114.114817.5e10ec8d.en.html

this report is interesting but we have to be very careful because trials of this drug has been stopped worldwide while it is still sold in the philippines
there are 2 problems, resistance and sides effect.if there is a way to predict development of  mitochondrial myopathy or prevent it a combo of clevudine with another drug might be considered but at research level or monitoring very closely for sides

in vitro combo of clevudine and ftc made the strongest decline of ccdna, i guess truvada+clevudine might prevent resistance 100%, let's hope some researcher will check for this and make possible reduction or control of this very dangerous sides effect of  mitochondrial myopathy (i think also telbivudine has similar sides)

sides that made clevudine stop
http://www.ncbi.nlm.nih.gov/pubmed/19712273

[stef2011]

NINDS Mitochondrial Myopathies Information Page

http://www.ninds.nih.gov/disorders/mitochondrial_myopathy/mitochondrial_myopathy.htm

quite scarry

[stef2011]

to make a sum of all drugs that have real potential to eradicate hbv (hbsag negative) or relevant decrease of hbsag

monotherapy:
peginterferon (11%)
nitazoxanide (25% but trials were too small and only for 1 year so it maybe much more or less especially combo with other durgs)

combiantion:
interferon+nitazoxanide
interferon+telbivudine (dangerous sides effects possible, close monitoring necessary)
entecavir+nitazoxanide (lowers hbsag too early to say how much eradication percentage is but of course more than ntz monotherapy)
tenofovir+nitazoxanide (no data yet but probable since case reports of ntz+adv)
interferon+entecavir (probable but not data yet, only case reports)
interferon+tenofovir (probable but not data yet, only case reports)

all other therapies have almost no relevant effect except tenofovir on hbeag positive 16% in 3-4 years, maybe more in the following years but on hbeag neg eradication of hbsag is still 0%

all other monotherapies no relevant effect on hbsag

[stef2011]

https://springerlink3.metapress.com/content/m5m68831888p2848/resource-secured/?target=fulltext.pdf&sid=yso2r1briuwri1msk1lo2aya&sh=www.springerlink.com

full article, it would be interesting to see how long the treatment was, if response is achieved very fast short periods of combo might be accepted