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interesting study on hbv immune suppression by TRLs
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interesting study on hbv immune suppression by TRLs

http://onlinelibrary.wiley.com/doi/10.1002/hep.22751/pdf

interesting to have an idea how trl agonists on human trial may help start an immune response to hbv

Discussion
In this article, we demonstrate that HBV can suppress
the innate immune response elicited by TLR stimulation
of hepatocytes and nonparenchymal liver cells. The data
suggest that HBV-bearing supernatants, purified HBV
virions, and recombinant HBsAg or HBeAg can induce
this effect. The inhibitory effect is at least partially mediated by suppression of IRF-3 activation resulting in
down-regulation of IFN- production and subsequent
ISG expression, which leads to reduced TLR-mediated
induction of antiviral activity against EMCV and HBV.

In conclusion, our data indicate that HBV can counteract the antiviral response of the local innate immune
system of the liver by antagonizing TLR-mediated induction of proinflammatory cytokines. This is of relevance
for our understanding of the interaction of HBV and the
innate immune system and may, at least in part, explain
why HBV appears to act as a “stealth virus” in the initial
phase of the infection
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