my alt is 8 but my hbv-dna is 30,000iu/ml or 200,000 copies /ml

[aderts]

how come my alt is very low while my hbv-dna is high?? when you have high hbv-dna means that your liver is prone to be damaged, am i right??

[stef2011]

is it ok for me to take therapy with my hbv-dna high although my alt is low?
if therapy works alt will get higher and hbvdna und so your HCC risk becomes almost zero.
until hbsag negative and hbsab positive, can be decades or life

possibly how long should i be in therapy??
until you don t get rid of hbsag probably all life and dye of other causes then HCC.If you have genotype C it is also linked to fast cirrhosis on latest studies, they just found how it promotes cirrhosis, genotype B promotes cirrhosis too but like all other genotypes

it is moderate/high but low for asians that usually have it in the millions, those with the highest hbvdna in the millions often cannot even clear hbvdna with drugs since immune response is very low.you are lucky to have hbe neg and low hbvdna and all drugs work

the best situation is high alt and low hbvdna because it means there is a strong immune response

[aderts]

is it ok for me to take therapy with my hbv-dna high although my alt is low? possibly how long should i be in therapy??

is 30000 iu/ml or 200000 copies/ml really that high?? the doctor  said some patients could reach their dna's to million copies/ml...

[stef2011]

ok that says nothing to worry at the moment and there is no hcc but remember to check every 6 months because hcc if not resectable (after 6 months grown it isnt anymore) is equal to death, no cure

risks:
hbsag pos moderate
liver fibrosis moderate
hbvdna if detactable over 2000iu/ml high risk
bcp and precore high risk
asian and genotype B or C highest risk
family history HCC highest risk
cirrhosis highest risk but don t know
diabetes highest risk of liver cancer more than liver desease

prevention ultrasound every 6 month, alfafeto can mean hcc when elevated but also other causes if normal does not esclude HCC

[aderts]

but i also had an ultrasound.. and it says normal..

[stef2011]

alphafetoprotein(tumor marker)
not valid anymore because about 50% HCC have normal values, only ultrasound can detect tumores, as to markers there are new ones but i will not talk about it since available only in italy main hospitals and maybe some research center around the world

alphafetoprotein(tumor marker) tells nothing about risk, if it is your doctor saying so change doctors he is using info from 2000 or maybe even earlier, in this field there are updates yearly lately and many old things are wrong

the risk is given only by wht i told you above but i am sorry that probably in india there is nothing of those test available

[aderts]

i had a test called alphafetoprotein(tumor marker), which is use to diagnose for tumors or liver cancer or HCC...
and it says my alphafetoprotein is normal... so for now i am not at risk with HCC.. this is just my assumption...

[stef2011]

your immune system cannot see infected cells and clear them so there is a lot of virus replicating, this is a bad condition dispite low alt because if infected cells are not killed they can produce many many complete virions

you are also in high risk hcc due to this, hcc risk is also increased by your hbv genotype, hbe negative condition if you have precore or BCP, family history hcc.As to liver damage only fibroscan can tell 100%, not alt and not hbvdna

if you are able to understand this study explains the known ways of virus replication/damage
http://pubget.com/search?q=authors%3A%22Maura%20Dandri%22