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new form of activated vitamin d
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new form of activated vitamin d

http://www.gcmaf.eu/info/index.php?option=com_content&view=article&id=161&Itemid=120

researchers have found that vitamin d needs oleic acids to bound to gcmaf which bounds to vdr receptor on immune cells influencing trl7 the most

i have no idea if this form of vit d can be more active on hbv than normal vit d3, too early to say, but i think it would be useful if some members use this

of course we need a member with vit d deficency so it is easier to see if there is any difference with normal vit d3, since latest human trials showing inactive carriers have high vit d and that vit d influences trl7 receptors this diserves our attention
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Avatar_m_tn
hbsag quantity and hbvdna, ast-alt should be measured baseline and then every 4 weeks together with vitd25oh to see if this form can have more activity on hbv
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Avatar_m_tn
what should be the method. oleic acid add on with normal vit d or some other method or compound.
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Avatar_m_tn
they found that:

immune cells have vdr receptor to be activated, this receptor needs vitd+oleic acid+gcmaf in order to have immune cells activated so they made a type of vit d which has the oleic acid included....if any of these is missing there is no attachment to vdr receptor

https://www.youtube.com/watch?v=Bu0AuPo50_k

minute 07:58
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Avatar_m_tn
this is very interesting

http://rrml.ro/articole/2013/2013_1_11.pdf

The serum level of the immunomodulatory peptide
cathelicidin LL37 and T helper cell type 1 inflammatory
response in viral hepatitis B, C, and D

inactive hbv has been found with:
LL37 serum level (ng/ml)±SD 174.66
IFN-γ serum level (pg/ml) 70.23
CD4 cell count/mm3±SD818.80 ± 358.66
CD8 cell count/mm3±SD551 ± 340.85
CD4/CD8 ratio ±SD1.37 ± 0.62

active hbv has been found with:
LL37 serum level (ng/ml)±SD 76.75
IFN-γ serum level (pg/ml) 24.57
CD4 cell count/mm3±SD866.88 ± 352.03
CD8 cell count/mm3±SD539.85 ± 176.31
CD4/CD8 ratio ±SD1.64 ± 0.41

so just my guess the higher the vit d, the higher gcmaf (which equals lower nagalase), the higher LL37 serum level from immune cells and  LL37 has an antiviral effect
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Avatar_m_tn
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532295/

Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults

but i have found other studies on different diseases from tbc to sepsis, psoriasis and so on....phatogens make this correlation very weak, they probably influence this balance by nagalase and other ways to block vdr receptor so that no LL37 cathelicidin is produced
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