ketoconazole makes damage to hbsag lipids probably the same way as statins do.if you use these pills or statins you must check liver function monthly because although rare both statins and especially ketoconazole might make liver damage and in that case it is better to stop these pills
i also suggest to use antioxidants like fibroguard, heptech, heptoshield, liposomal glutathione and liposomal vitamin c, these antioxidants will probably block any liver damage.i am using this products continuatively to reverse all cirrhosis
How does it work?
Nizoral tablets contain the active ingredient ketoconazole, which is a type of medicine called an antifungal. It is used to treat infections with fungi and yeasts.
Ketoconazole kills fungi and yeasts by interfering with their cell membranes. It works by stopping the fungi from producing a substance called ergosterol, which is an essential component of fungal cell membranes. The disruption in production of ergosterol disrupts the fungal cell membrane, causing holes to appear in it.
The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As ketoconazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi and treats the infection.
When taken by mouth ketoconazole may very rarely cause serious side effects on the liver. As a result, Nizoral tablets are reserved for treating fungal infections that can't be treated with other antifungals.
this is another clear example of how drug makers avoid ANY study about hbsag reduction.......it is better to check research ourselves since most of these drugs are already approved from a long time and very cheap generics.
the evidence is that anything that destroys or lowers lipids damages hbsag virus coat
Studies have demonstrated that ketoconazole and related imidazoles block gonadal and adrenal steroidogenesis in humans by inhibiting several cytochrome P-450-dependent enzymes. Moreover, recent evidence suggests that cholesterol production in humans is also affected by ketoconazole. In the present experiments cultured normal human fibroblasts have been used to explore the effects of ketoconazole on cholesterol synthesis. Ketoconazole inhibited cholesterol synthesis (greater than 90% suppression in 1 hr) rapidly by blocking the conversion of methyl sterols to cholesterol. Dihydrolanosterol was the major methyl sterol which accumulated with ketoconazole. At high concentrations of ketoconazole, the conversion of squalene to methyl sterols was also inhibited. The inhibition of cholesterol synthesis was dose-dependent with an IC50 approximately 2.8 X 10(-8) M. In parallel to the inhibition of cholesterol synthesis, there was a reciprocal increase in methyl sterol production. The related imidazole antimycotic, clotrimazole, had similar effects, whereas the imidazole anesthetic, etomidate, had little effect on cholesterol synthesis. Confluent cells exposed to ketoconazole had a 90% fall in the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase that declined with a T1/2 approximately 3.7 hr. In conclusion, ketoconazole has multiple effects on cholesterol synthesis, directly inhibiting late steps by blocking the conversion of methyl sterols to cholesterol and indirectly suppressing total sterol synthesis via feedback inhibition by sterol intermediates of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.
Thanks stef2011. Frankly, I am very confused by Cholesterol lowering drugs such as statin. It seems they can be good and bad at the same time for Hepatitis B patients. I hope you can clarify the situation for all of us.
they are not bad, they have tried to prevent their use in the past by stating that they make liver damage but all those statments were false and not from well known liver researchers, on the contrary they have shown to prevent cirrhosis, portal hypertension and liver cancer
of course liver damage can happen in rare cases but this is the same for any drug and compared to the simple aspirin the statin are much less toxic.
so close monotoring of liver function must always be done for any therapy and drug, even when taking vitamins, at least we know what good or bad we are doing.
we are now lucky because we have about the same tests used at research level available, and most of the time we even do better tests than them
i do suggest monthly liver function tests, especially those who have free tests, insurance or those who can afford even if there is no toxcity at all when using statins, ketoconazole
they are very expensive, i suggest to se them only if you can afford them without anytrouble otherwise use only if you have liver damage or cirrhosis
as to all the others it is possible to get similar benefits by the diet since most of the ingredients are spieces and food, of course i dont think severe fibrosis or cirrhosis can be regressed by diet only, probably a balance of the quantities from those nutrients is needed (more concentrated than what can e found in the food)....but all those without liver damage can probably keep liver healthy by diet only
this is an antioxidant therapy to balance the oxidative stress due to immune system failing to clear hbv and just damaging the liver, oxidative stress tests are not commercially available but two labs can do it even for single patients.if you want to check it or monitor if antioxidant therapy is working you can send blood samples to these research labs:
Thanks a lot stefano..I am already having a good diet and i am feeling good..I have posted my results in a separate post. I am planning to take up Fibroscan (I am from India) in the next two weeks. It would be costing me aroun 500 USD (including flight charge). How often we need to go for Fibroscan? Can we change the frequency if the value is LOW (for example less than 2kpa)
I went to VGM and they told me that they have sent it back as they are not able to do scan for patients with higher BMI (in the range of 28 and above) and they will be getting a newer version of the machine in three months time. (i have already posted the details in one of the threads). Now i am planning to go to mumbai for the test. The test cost is 12.5K and the doctor's fee is 2.5K and add flight charges on top of it.
i'd check yearly if you detect liver damage, for example fibrosis 7kpa or higher so you can monitor if diet and antioxidants are working to decrease it.if you find it less than 6kpa you can check yearly and then check alt/ast and hbvdna becuase if these ones stays in the normal range it is very difficult to make liver damage
i do it every 6 months with ultrasound but i had cirrhosis and curing fibrosis so it is another story.for those who can afford without any trouble fibroscan every 6 months is the best monitoring
low bmi, no fatty liver and alt less than 200 or possibly normal are the best to pick the exact amount of fibrosis and excluse the inflammation or fat from the scan
i think you should try a couple of months with alinia+sim+liposomals and if hbsag stays the same try nizoral pills (ketoconazole) too
at the moment you are the best example and you are going to clear hbsag in any case, interferon+alinia would take about 24weeks to lower hbsag to 5iu/ml since all respond to interferon when hbsag is so low
the use of liposomal vitamin c at 5 to 10 bags throughout the day equals to 50-100gr of vitamin c.these high doses make the body produce interferon naturally and are the doses used on cancer trials
this is an example story where the doses used where 25gr, leukemia+swine flu dying patient
interferon production by the body has been reported on 25g-50g so i d try 50gr for now (5 bags).it has no sides but only liposomal or intravenous, the normal vitamin c tablets have saults that damge the stomach and are very very poorly absorbed at high doses
the max is about 100gr (10bags) this dose was used on cancer trials but i d go on this dose only if we see a big improvment from 50gr since this lipo c is very expensive
the cheap option might be intravenous vit c but this is just for the drug itself since you have to pay the doctor for this
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