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nizoral tablets might damage hbsag, in vitro reduction 72%
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nizoral tablets might damage hbsag, in vitro reduction 72%

http://onlinelibrary.wiley.com/doi/10.1002/jmv.1890160308/abstract

ketoconazole makes damage to hbsag lipids probably the same way as statins do.if you use these pills or statins you must check liver function monthly because although rare both statins and especially ketoconazole might make liver damage and in that case it is better to stop these pills

i also suggest to use antioxidants like fibroguard, heptech, heptoshield, liposomal glutathione and liposomal vitamin c, these antioxidants will probably block any liver damage.i am using this products continuatively to reverse all cirrhosis

How does it work?
Nizoral tablets contain the active ingredient ketoconazole, which is a type of medicine called an antifungal. It is used to treat infections with fungi and yeasts.
Ketoconazole kills fungi and yeasts by interfering with their cell membranes. It works by stopping the fungi from producing a substance called ergosterol, which is an essential component of fungal cell membranes. The disruption in production of ergosterol disrupts the fungal cell membrane, causing holes to appear in it.
The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As ketoconazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi and treats the infection.
When taken by mouth ketoconazole may very rarely cause serious side effects on the liver. As a result, Nizoral tablets are reserved for treating fungal infections that can't be treated with other antifungals.
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28 Comments Post a Comment
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Avatar_m_tn

this is another clear example of how drug makers avoid ANY study about hbsag reduction.......it is better to check research ourselves since most of these drugs are already approved from a long time and very cheap generics.
the evidence is that anything that destroys or lowers lipids damages hbsag virus coat
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Avatar_m_tn
Stef, I thought this is talking about fungi and not viral infection. Does it work the same way? Meanwhile, just wish to know. Are you a medical doctor?
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Avatar_m_tn

the reason of activity on hbsag

Abstract

Studies have demonstrated that ketoconazole and related imidazoles block gonadal and adrenal steroidogenesis in humans by inhibiting several cytochrome P-450-dependent enzymes. Moreover, recent evidence suggests that cholesterol production in humans is also affected by ketoconazole. In the present experiments cultured normal human fibroblasts have been used to explore the effects of ketoconazole on cholesterol synthesis. Ketoconazole inhibited cholesterol synthesis (greater than 90% suppression in 1 hr) rapidly by blocking the conversion of methyl sterols to cholesterol. Dihydrolanosterol was the major methyl sterol which accumulated with ketoconazole. At high concentrations of ketoconazole, the conversion of squalene to methyl sterols was also inhibited. The inhibition of cholesterol synthesis was dose-dependent with an IC50 approximately 2.8 X 10(-8) M. In parallel to the inhibition of cholesterol synthesis, there was a reciprocal increase in methyl sterol production. The related imidazole antimycotic, clotrimazole, had similar effects, whereas the imidazole anesthetic, etomidate, had little effect on cholesterol synthesis. Confluent cells exposed to ketoconazole had a 90% fall in the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase that declined with a T1/2 approximately 3.7 hr. In conclusion, ketoconazole has multiple effects on cholesterol synthesis, directly inhibiting late steps by blocking the conversion of methyl sterols to cholesterol and indirectly suppressing total sterol synthesis via feedback inhibition by sterol intermediates of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.
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Avatar_m_tn
Ketoconazole inhibited cholesterol synthesis (greater than 90% suppression in 1 hr) rapidly by blocking the conversion of methyl sterols to cholesterol.

this is really a lot.....i wonder if this is more potent than statins

http://jpet.aspetjournals.org/content/238/3/905.short

here is a full article, i will read it fully later
chol kinetics ketoconazole
http://www.jlr.org/content/34/1/59.full.pdf+html
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Avatar_m_tn

cholesterol is linked to viral, bacterial infections and cancer.depletion of cholesterol starve hbv which cannot make antigens and assemble virions inside the cells
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Avatar_m_tn
Thanks stef2011. Frankly, I am very confused by Cholesterol lowering drugs such as statin. It seems they can be good and bad at the same time for Hepatitis B patients. I hope you can clarify the situation for all of us.
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Avatar_m_tn

they are not bad, they have tried to prevent their use in the past by stating that they make liver damage but all those statments were false and not from well known liver researchers, on the contrary they have shown to prevent cirrhosis, portal hypertension and liver cancer

of course liver damage can happen in rare cases but this is the same for any drug and compared to the simple aspirin the statin are much less toxic.

so close monotoring of liver function must always be done for any therapy and drug, even when taking vitamins, at least we know what good or bad we are doing.
we are now lucky because we have about the same tests used at research level available, and most of the time we even do better tests than them

i do suggest monthly liver function tests, especially those who have free tests, insurance or those who can afford even if there is no toxcity at all when using statins, ketoconazole
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Avatar_m_tn

of course hbsag quantification is a must and done every 3-6 months, our goal is hbsag reduction

of course statins and ketoconazole are meant to be used in combo with tnf or etv or inf or ntz, they have no meaning as monotherapy since theyhave almost no activity on hbvdna
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Avatar_m_tn
How many bottles do i need from (HepTech) and (Fibroguard) from Hepatitistechnologies?
Do i need to use them forever to protect liver?

Thanks,
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Avatar_m_tn
Hi stefano,
How much it would cost to get the Hepatitistechnologies products in india? I am willing to buy it if the cost is reasonable


thanks
Raja
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Avatar_m_tn

they are very expensive, i suggest to se them only if you can afford them without anytrouble otherwise use only if you have liver damage or cirrhosis

as to all the others it is possible to get similar benefits by the diet since most of the ingredients are spieces and food, of course i dont think severe fibrosis or cirrhosis can be regressed by diet only, probably a balance of the quantities from those nutrients is needed (more concentrated than what can e found in the food)....but all those without liver damage can probably keep liver healthy by diet only

this is an antioxidant therapy to balance the oxidative stress due to immune system failing to clear hbv and just damaging the liver, oxidative stress tests are not commercially available but two labs can do it even for single patients.if you want to check it or monitor if antioxidant therapy is working you can send blood samples to these research labs:

www.redlabs.com
www.europeanlaboratory.nl
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Avatar_m_tn
Stef ..
Is one bottle of heptech and fibroguard enough or i have to use more than one?

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Avatar_m_tn

just check their website, bottles are for 1 month supply...as to regression of fibrosis it varies a lot especially if hbvdna is undetactable or detactable

without a fibroscan it is not possible to monitor fibrosis and improvment, so those countries without fibroscans have no tolls to detect and monitor liver damage properly
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Avatar_m_tn
Thanks a lot stefano..I am already having a good diet and i am feeling good..I have posted my results in a separate post.  I am planning to take up Fibroscan (I am from India) in the next two weeks.  It would be costing me aroun 500 USD (including flight charge).  How often we need to go for Fibroscan?  Can we change the frequency if the value is LOW (for example less than 2kpa)
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Avatar_m_tn
Hi,

Whether Fibroscan is available in VGM hospital, coimbatore or not? What they told you. Could you please share those details - cost etc
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Avatar_m_tn
Hi,
I went to VGM and they told me that they have sent it back as they are not able to do scan for patients with higher BMI (in the range of 28 and above) and they will be getting a newer version of the machine in three months time.  (i have already posted the details in one of the threads).  Now i am planning to go to mumbai for the test.  The test cost is 12.5K and the doctor's fee is 2.5K and add flight charges on top of it.

regards
raj
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Avatar_m_tn

i'd check yearly if you detect liver damage, for example fibrosis 7kpa or higher so you can monitor if diet and antioxidants are working to decrease it.if you find it less than 6kpa you can check yearly and then check alt/ast and hbvdna becuase if these ones stays in the normal range it is very difficult to make liver damage

i do it every 6 months with ultrasound but i had cirrhosis and curing fibrosis so it is another story.for those who can afford without any trouble fibroscan every 6 months is the best monitoring

low bmi, no fatty liver and alt less than 200 or possibly normal are the best to pick the exact amount of fibrosis and excluse the inflammation or fat from the scan
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Avatar_m_tn
Hi,
Its too costly. Please share the Mumbai Hospital details.Also It would be useful for other people too
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Avatar_m_tn

i think you should try a couple of months with alinia+sim+liposomals and if hbsag stays the same try nizoral pills (ketoconazole) too

at the moment you are the best example and you are going to clear hbsag in any case, interferon+alinia would take about 24weeks to lower hbsag to 5iu/ml since all respond to interferon when hbsag is so low

the use of liposomal vitamin c at 5 to 10 bags throughout the day equals to 50-100gr of vitamin c.these high doses make the body produce interferon naturally and are the doses used on cancer trials

this is an example story where the doses used where 25gr, leukemia+swine flu dying patient

http://www.3news.co.nz/Living-Proof-Vitamin-C---Miracle-Cure/tabid/371/articleID/171328/Default.aspx
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Avatar_m_tn
the doctor's name is NH BHANKA and his clinic number is 022 26249475.  Website; http://nhbanka.com/ ( he claims to have done the fibroscan in india for the first time)
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Avatar_m_tn
Thanks for the post.

I will see th video once I go back to the home. Stef please confirm whether I should increase Liposomal Vit C to 5 packs ?

Currently I'm taking one pack in empty stomach?
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Avatar_m_tn

interferon production by the body has been reported on 25g-50g so i d try 50gr for now (5 bags).it has no sides but only liposomal or intravenous, the normal vitamin c tablets have saults that damge the stomach and are very very poorly absorbed at high doses

the max is about 100gr (10bags) this dose was used on cancer trials but i d go on this dose only if we see a big improvment from 50gr since this lipo c is very expensive

the cheap option might be intravenous vit c but this is just for the drug itself since you have to pay the doctor for this
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Avatar_m_tn
Thanks for the advice - should monitor liver functions when on statin.
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Avatar_m_tn
Hi Stef,

What is intravenous vit c . its Injection or Tablet?

I feel Liposomal Vit C is bit costly for me. it cost 100 INR per bag . I would prefer intravenous vit c

thanks
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Avatar_m_tn
http://www.youtube.com/results?search_query=intravenous+vitamin+c&aq=f

you need a doctor to do it so the problem might be doctor charge

here's a guy who administers himself but you must be perfectly trained because this is very very dangerous

http://www.youtube.com/watch?v=mgRoR1-qw8Y
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Avatar_m_tn
Hi smile_boy,
whether Liposomal Vit C is available in chennai?  If so, please let me know from where i can get it.

Thanks
Raja
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Avatar_m_tn
Hi,

Its not available in India. You should it order it through online stores.

I ordered from www.iherb.com (iherb) , bcoz shipping cost is minimum in that website. You will get it within 15 day from date of order. Also You have to pay customs dutyu on above total cost(~15%)
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Avatar_m_tn
thanks for the info.  I will look into the website.
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