91% clearance and 100% response in lowering hbsag was in sequential treatment with hbsag less than 1000iu/ml
no data about peginterferon mono, we only know response is highest.
there was a study on hbvdna und inactive carriers long time ago at a easl conference, they did not check hbsag quantity at that time but it was probably less than 1000iu/ml.response for 48weeks was 30%, i dont remember if 30% clearance was within 48weeks or 5years follow up
Yeah but I think the 91% was for eag positive isn't ? Also with my low hbsag And Hbv DNA around 40000 iu from your opinion how long will it take me to clear hbsag on mono therapy such as peginterfron as I never took any medicine in the past. My appointment is this Wednesday I'm just preparing my questions to the doctor just in case she ask me to take viread only
hbvdna is not so low so i d try pegintf mono for 24 weeks if no big hbsag and hbvdna decline i d go for tdf and then pegintf add on in 1 year.i think that with peg you have to try and see then correct according hbsag levels
ask the doctor for the personalized hbv treatment according hbsag levels that most expert researchers/liver specialists are applying in italy
ok great lets all take nucs for 10 years and hope our hbsag level is below 1000iu/ml then hope peg can clear our hbsag..... great stef2011.... tell me if this is so great then why have you not put it into use? post your results of this cure you speak of and we can all believe........
this is spam...... if this worked we would all be on it.....
false hope.............. stef2011 also posted alinia was the cure....... did that work for anybody? cure to make hbsag positive to negative was your words..... stop misleading people with your theories
I am in no position to speak about the treatment of hepatitis but have in mind that at least in my country until last year they treated hepatitis b just to achieve undetectable hbvdna, they just started to watch hbsag quant .if nucs can lower hbsag, in a few years it is logic that this can be possible after many years to achieve seroconversion. I didnt seen official trials on this but speaking of this, stef, do you have some links on this ? Let's hope that replicor will manage to get to the market their arc vaccine in the next years
Me, you and Steff are not scientists, nor researchers. This is said because of study done by researchers.
Professor Cihan Yurdaydin from the Department of Gastroenterology, University of Ankara, Turkey, have conducted this study and had presented on liver conference 2014
192 patients who had received at least two years treatment with NUCs without achieving HBeAg loss or seroconversion were treated with 48-week combination therapy with additional Peg-IFN to on-going NUCs or NUCs monotherapy.
Out of this population, 83 patients were treated with combination therapy and 109 patients were treated with NUCs monotherapy. All patients were followed for a further 24 weeks and the HBsAg level was measured both during treatment and post-treatment.
Where is your prof that mostly do not reduce hbsag on nucs? I think that Steff is not misleading anybody, but thanks to him we know much more about hep B. Personally I would thank him,for taking his time to response to everybody,advising them for what he has done through his experience,bringing latest news from pisa's researchers and what is reading from internet. If you have prof for your saying you are very welcome as well.
my main point is discussion that helps patients now with the cures we have available now, with such high cure rates reported we need to focus on these sequential therapies and also look in to possible improvement of response from 91 to 99%
we just need to apply this and confirm in our daily clinical experiences
i am a mom, i am new in your community..my son supposed to be in ksa now but due to his finding that he has a mild fibrosis and doctor told him to take entegard 5mg daily...i don't know more of this virus. please help educate especially the treatment, its a very great help for me to read your reply.
First of all, this method is brought from doctors at international liver meeting, with their research done with their real patients, google it. second you must read old posts to see who they are,because they are not coming back here anymore
hbsag around 699iu/ml (still moving), vitd25oh probably around 2000ng/ml (not checking this anymore because not reliable on vit d deficiency for me but checking pth/calcium), pth 8-14pg/ml (10-72), calcium 9.8 mg/dl (8.1-10.4)), urine calcium 141mg/24h (50-400)
I talked with my doctor today regarding this add on combo, and he was actually very open to discussion.
He told me that they tried this combo on 20 patients and the success rate was not as good as they had hoped. They said out of the 20 patients, 2 cleared the virus.... both of them were of Genotype A.
He said that if I was Genotype A, he would suggest trying it after a few years on NUCs but in the meantime, he does not feel it would cure me but could "help" and admitted that this combo therapy is not the answer they were looking for... they were looking for an actual quick CURE combination drug like the Hep C drug that had come out.
I found it interesting that he was open to discussion. On top of this, he was VERY intrigued by the latest news from the drugs in clinical trials we have been posting because he wanted to learn more about them and what his office could do with them, if at all possible.
I'm glad I found a doctor who is willing to listen and not give a bias opinion and just throw drugs at me and tell me to be on my way!
there is zero drugs available at all now and this will be so for many years
only pegintf add on when hbsag is less than 1500iu/ml after 5 years on tdf or etv is available now (and free in many euro countries which is not bad), with this sequential the result is not 2 on 20patients and genotype is irrelavant, that is the statistics of studies on simple peg plus nuc combos
all the rest is just talk, post the trial published on sceintific journal otherwise what you say i am sorry is zero value and does not help anyone.
i posted studies here or my own result on sequential even with high hbsag, please avoid the talk and a doctor's talk is also zero values with all the dumbs around in hepatology if there is not a published study
Nice post Steff, reading posts on this community gives strength to keep on fighting and not lose hope. I used to think what if my peg therapy fails? But now I think there still will b way ahead. Although after my peg session I will stop all combo drugs like ntz artesunate and ayurved but continue only tdf and live happily hoping some of u will give some news about the latest curing drug.
Just adding my hbsag as this post wants, it was 6840iu/ml 8weeks back. Will check at 12 weeks and upload here.
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