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nucs peg add on combo with 100% response and 91% hbsag loss

this was posted already but it is better to enhance this data for all members and for all readers and keep this thread up all the time and separated

baseline hbsag<1000iu/ml has 100% response and 91% hbsag loss

http://medicalxpress.com/news/2014-04-optimal-combination-therapy-chronic-hepatitis.html
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Avatar universal
Nice post Steff, reading posts on this community gives strength to keep on fighting and not lose hope. I used to think what if my peg therapy fails? But now I think there still will b way ahead. Although after my peg session I will stop all combo drugs like ntz artesunate and ayurved but continue only tdf and live happily hoping some of u will give some news about the latest curing drug.
Just adding my hbsag as this post wants, it was 6840iu/ml 8weeks back. Will check at 12 weeks and upload here.
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Avatar universal
i myself could get hbsag loss easily and fast with hbsag less than 600iu/ml by simply restarting pegintf over 48weeks till hbsag loss

but maybe i will get there slowly anyway by tdf mono, once hbsag is much less than 1000iu/ml the risks of hcc and liver damage are almost the same as for hbsag loss so no rush
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Avatar universal
there is another hbv community for doctors, here is for researchers or patients
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Avatar universal

there is zero drugs available at all now and this will be so for many years

only pegintf add on when hbsag is less than 1500iu/ml after 5 years on tdf or etv is available now (and free in many euro countries which is not bad), with this sequential the result is not 2 on 20patients and genotype is irrelavant, that is the statistics of studies on simple peg plus nuc combos

all the rest is just talk, post the trial published on sceintific journal otherwise what you say i am sorry is zero value and does not help anyone.

i posted studies here or my own result on sequential even with high hbsag, please avoid the talk and a doctor's talk is also zero values with all the dumbs around in hepatology if there is not a published study

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Avatar universal
Unfortunatelly not many doctors are interested in learning new stuff after many years of work.

luckyman316 it would be great if he would participate in the forum too.
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Avatar universal
Consider this a free bump, Stef!

I talked with my doctor today regarding this add on combo, and he was actually very open to discussion.

He told me that they tried this combo on 20 patients and the success rate was not as good as they had hoped. They said out of the 20 patients, 2 cleared the virus.... both of them were of Genotype A.

He said that if I was Genotype A, he would suggest trying it after a few years on NUCs but in the meantime, he does not feel it would cure me but could "help" and admitted that this combo therapy is not the answer they were looking for... they were looking for an actual quick CURE combination drug like the Hep C drug that had come out.

I found it interesting that he was open to discussion. On top of this, he was VERY intrigued by the latest news from the drugs in clinical trials we have been posting because he wanted to learn more about them and what his office could do with them, if at all possible.

I'm glad I found a doctor who is willing to listen and not give a bias opinion and just throw drugs at me and tell me to be on my way!
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Avatar universal
this is awesome Stef.
Thanks for bumping this thread up, otherwise i wouldn't haven't read it.
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Avatar universal
waw very impressing mio amico, auguri , I can't wait to see your happiness on your face
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Avatar universal
thanks
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Avatar universal
Good luck man! Finger crossed
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Avatar universal
i will post as therapy is finished and doses are clear

it is me to know my therapy, not you
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Avatar universal
as per my knowledge you are not on pegintff last year,
when you start pegintff at what level of hbsag and what is your vitamin d3 level last year I think it is above 50 what is know.
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Avatar universal
Are You now on combo treatment (viread+interferon)?
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Avatar universal
i will report everything as i reach final results of the combination and doses will be clear
of course pegintf was part of these results even if hbsag was much higher than 1000iu/ml
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Avatar universal
Congratulation Steff! Hbsag 699iu/ml it is good. Why You don't try interferon?
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Avatar universal
baseline august 2013 2900iu/ml

december 2014
hbsag around 699iu/ml (still moving), vitd25oh probably around 2000ng/ml (not checking this anymore because not reliable on vit d deficiency for me but checking pth/calcium), pth 8-14pg/ml (10-72), calcium 9.8 mg/dl (8.1-10.4)), urine calcium 141mg/24h (50-400)
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Avatar universal

Dear steff,

I would like to  here your recent hbsag level and Vitamin D3 level.
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Avatar universal
i apolagise i did not meed to be distruptive here.
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Avatar universal
The study you posted has nothing to do with this treats and its studies.

this is sequential combo after 5-7 years of nucs and pegintf add on and not 48weeks but personalised on response of hbsag, also add is when hbsag less than 1000iu/ml

these are not simple combination studies at all because they fail, there is no cd8 rescue by pegintf plus nucs simple combo
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Avatar universal
See answers to hatehepb (you are adding nothing useful or new to this post), all your answers are here already by many old memebers
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Avatar universal
Just browse back old posts, about 10 members and dont bother other members.if you are here to help welcome, if uou are here to bother back off where you came from
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Avatar universal
http://onlinelibrary.wiley.com/doi/10.1002/hep.27480/full

many studys i look at never show 91% loss rate.
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Avatar universal
name 1 for me, i only ask because i read many posts, i see people have used nucs, or peg, but anybody who had done the same as the study i only ask, you think i do not look at google?
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Avatar universal
First of all, this method is brought from doctors at international liver meeting, with their research done with their real patients, google it. second you must read old posts to see who they are,because they are not coming back here anymore
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