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overcoming intf resistance on HCV (may apply to hbv too)
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overcoming intf resistance on HCV (may apply to hbv too)

http://hcvets.com/Journals/IRTreatmentResistance.pdf

these steps in the poster may apply to boost intf response on hbv

Treatment Summary
Reduced  HOMA-IR from 2.44 to 1.2; Weight from ~77 to
70kg; BMI from ~25.7 to 23.3; Waist circumference from ~93
to 87cm SAMe + TMG, Vitamins B12 & Folate pre-treatment.
Anti-inflammatory  and anti-fibrotic supplements were
stopped and dose of SAMe & TMG increased at least 6
weeks prior to starting Treatment. Anti-oxidants continued.

1. Pre-dosed Ribavirin for 2 weeks.
2. Pre-dosed Nitazoxanide* for 2 weeks.
3. Nitazoxanide further 8 weeks.
4. Titrated RBV dose to maintain a ≥3 g/dL drop in Hb.
5. High-dosed PegIFNα-2b tapered to 120 mcg/wk over 8 wks.
6. Supplemental Vitamin D3.
7. Duration 36 weeks (based on response).
 First in Australia given TGA approval for Nitazoxanide use
in HCV therapy
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