RESPONSE TO PEGINTERFERON ALFA-2A IN HBeAg NEGATIVE CHB: BASELINE AND ON-TREATMENT KINETICS OF HBsAg SERUM LEVELS VARY ACCORDING TO HBV GENOTYPE
see full poster and charts in the link
In genotype A, 100% (3/3) of responders had HBsAg≤400 IU/mL vs 10% (1/10) of NR/relapsers. In genotype B, 100% (7/7) of responders had HBsAg≤50 IU/mL vs 14% (8/57) of NR/relapsers. In genotype C, 41% (11/27) of responders had HBsAg≤50 IU/mL vs 6% (4/64) of NR/relapsers. In genotype D, 60% (6/10) of responders had HBsAg≤1000 IU/mL vs 9.5% (2/21) of NR/relapsers.
This paper showed there is still much to be learned about qHBsAg kinematics. A good comment on the paper can be found here:
"The key message for clinicians is that ... it is mandatory to know the HBV genotype" in patients undergoing pegIFN treatment," Dr. Maurizia Brunetto of Azienda Ospedaliero Universitaria Pisana in Pisa, Italy, told Reuters Health by email.
Dr. Brunetto's group found that genotype significantly influences hepatitis B surface antigen (HBsAg) levels before and during peginterferon treatment, and it also influences end-of-treatment HBsAg levels that are associated with long term virological response.
Is there any open trial that i can participate on for HBSag less than 200 ui/ml Genotype D or better wait until i got good level of vit D to confirm if this latter could be the answer to HBSag seroconversion for people wigh very low HBSag.
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