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pietro lampertico/our target is not hbsag loss but decline
http://www.aphc.info/videos-replay-2015/
very interesting point from dr.pietro lampertico at this conference:
the target on sequential therapy by adding peg after years of nucs use is not hbsag loss but hbsag decline below 1000iu/ml, afterall the different between hbsag loss and hbsag below 1000iu/ml is very little in terms of risk of cirrhosis and HCC....for me i would be satisfied by a level below 400iu/ml
this target of hbsag below 1000iu/ml is achieved by a very large number of patents in the sequential add on
very interesting point from dr.pietro lampertico at this conference:
the target on sequential therapy by adding peg after years of nucs use is not hbsag loss but hbsag decline below 1000iu/ml, afterall the different between hbsag loss and hbsag below 1000iu/ml is very little in terms of risk of cirrhosis and HCC....for me i would be satisfied by a level below 400iu/ml
this target of hbsag below 1000iu/ml is achieved by a very large number of patents in the sequential add on
Thanks Steff...
For those who were not able to locate the video, here is the link:
http://rich-media.fr/projects/oxygenstream/?c=PHC3
I will have to measure my HBsAg...to know where I stand...
For those who were not able to locate the video, here is the link:
http://rich-media.fr/projects/oxygenstream/?c=PHC3
I will have to measure my HBsAg...to know where I stand...
you have to choose sessions, i think hbv is next day, very bad software it took me a while to get video the big size i like and find hbv sessions
1. If one lowers hbsag to <1,000 iu/ml is this sustainable, or off treatment does hbsag just rise again over years?
it depends on so many things, better stay on treatment according to me
2. Would most of us on NUC's attain the <1,000 iu/ml over years anyway?
no, only tdf has shown good decrease at 5 years on most patients, one study reported about 50% patients
Would this mean that even without INF and loss of hbsag one could achieve these goals of maintaining low hbsag and lower hcc/cirrhosis risk by NUC's alone (or does INF need to be added to reach these benefits)?
i think most will need an intf add on to reach hbsag less than 1000iu/ml, especially those not using tdf.
3. Several clinical trial meds are in the works to lower hbsag. In the future is it possible to see some of these drugs used with NUC's to maintain that <1,000 iu/ml (if hbsag is not lost) to achieve low hcc/cirrhosis...or back to #1 would hbsag just risk again over time once any drug that lowered hbsag is stopped?
until now only replicor plus peginterferon has worked but i dont think we will seee this drug ever approved....i think it would be faster to do the drug ourselves
4. For all of us the goal is to rid hbsag of course, but since this article points out goal may be to <1,000 iu/ml......is it plausible in the future for us to take daily NUC's plus another med that lowers hbsag to treat just like any other chronic condition? This may be a stupid question, but I recently read that Viread started as an injectable and by tweaking was able to made it possible to process orally.
it is very easy to reach hbsag less than 1000iu/ml:
3-5 years on tdf plus vit d3
then 1 year of tdf+vit d3+pegintf
then hbsag less than 1000iu/ml is achieved on most and tdf+vit d3 can be kept for many other years with minimum risk of hcc or cirrhosis...if less than 400iu/ml even stopping all drugs can be tried
1. If one lowers hbsag to <1,000 iu/ml is this sustainable, or off treatment does hbsag just rise again over years?
it depends on so many things, better stay on treatment according to me
2. Would most of us on NUC's attain the <1,000 iu/ml over years anyway?
no, only tdf has shown good decrease at 5 years on most patients, one study reported about 50% patients
Would this mean that even without INF and loss of hbsag one could achieve these goals of maintaining low hbsag and lower hcc/cirrhosis risk by NUC's alone (or does INF need to be added to reach these benefits)?
i think most will need an intf add on to reach hbsag less than 1000iu/ml, especially those not using tdf.
3. Several clinical trial meds are in the works to lower hbsag. In the future is it possible to see some of these drugs used with NUC's to maintain that <1,000 iu/ml (if hbsag is not lost) to achieve low hcc/cirrhosis...or back to #1 would hbsag just risk again over time once any drug that lowered hbsag is stopped?
until now only replicor plus peginterferon has worked but i dont think we will seee this drug ever approved....i think it would be faster to do the drug ourselves
4. For all of us the goal is to rid hbsag of course, but since this article points out goal may be to <1,000 iu/ml......is it plausible in the future for us to take daily NUC's plus another med that lowers hbsag to treat just like any other chronic condition? This may be a stupid question, but I recently read that Viread started as an injectable and by tweaking was able to made it possible to process orally.
it is very easy to reach hbsag less than 1000iu/ml:
3-5 years on tdf plus vit d3
then 1 year of tdf+vit d3+pegintf
then hbsag less than 1000iu/ml is achieved on most and tdf+vit d3 can be kept for many other years with minimum risk of hcc or cirrhosis...if less than 400iu/ml even stopping all drugs can be tried
Thanks Stef. The video comes up as HepC treatment and tried poking around but couldn't find the study you were referring to. Several questions that come to mind that someone with more knowledgeable may have answers to?
1. If one lowers hbsag to <1,000 iu/ml is this sustainable, or off treatment does hbsag just rise again over years?
2. Would most of us on NUC's attain the <1,000 iu/ml over years anyway? Would this mean that even without INF and loss of hbsag one could achieve these goals of maintaining low hbsag and lower hcc/cirrhosis risk by NUC's alone (or does INF need to be added to reach these benefits)?
3. Several clinical trial meds are in the works to lower hbsag. In the future is it possible to see some of these drugs used with NUC's to maintain that <1,000 iu/ml (if hbsag is not lost) to achieve low hcc/cirrhosis...or back to #1 would hbsag just risk again over time once any drug that lowered hbsag is stopped?
4. For all of us the goal is to rid hbsag of course, but since this article points out goal may be to <1,000 iu/ml......is it plausible in the future for us to take daily NUC's plus another med that lowers hbsag to treat just like any other chronic condition? This may be a stupid question, but I recently read that Viread started as an injectable and by tweaking was able to made it possible to process orally.
1. If one lowers hbsag to <1,000 iu/ml is this sustainable, or off treatment does hbsag just rise again over years?
2. Would most of us on NUC's attain the <1,000 iu/ml over years anyway? Would this mean that even without INF and loss of hbsag one could achieve these goals of maintaining low hbsag and lower hcc/cirrhosis risk by NUC's alone (or does INF need to be added to reach these benefits)?
3. Several clinical trial meds are in the works to lower hbsag. In the future is it possible to see some of these drugs used with NUC's to maintain that <1,000 iu/ml (if hbsag is not lost) to achieve low hcc/cirrhosis...or back to #1 would hbsag just risk again over time once any drug that lowered hbsag is stopped?
4. For all of us the goal is to rid hbsag of course, but since this article points out goal may be to <1,000 iu/ml......is it plausible in the future for us to take daily NUC's plus another med that lowers hbsag to treat just like any other chronic condition? This may be a stupid question, but I recently read that Viread started as an injectable and by tweaking was able to made it possible to process orally.
sorry i dont remember but they talk about it in the video
the other good point of dr lampertico is that sequential combo add on allows response on all genotypes, so even genotype D which is the wrost, has response like other genotypes
the other good point of dr lampertico is that sequential combo add on allows response on all genotypes, so even genotype D which is the wrost, has response like other genotypes
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