repated liver biopsy results

[rohul]

this is my repeat liver biopsy show chronic hepatitis with moderate activity(hbv related) and mild steatosis
and fibrosis 4 and i am on tenfovir since more than eight months dna undetectable in march 10 2016 before that i was on entecavir and then i switched to tenfovir the dna was always low my dna was 461 iu/ml before
entecavir and 47 iu/ml before tenfovir but my lft is always elevated my last was 134 alt and firbrosis show chronic hepatitis and mild steatoisis i am worry and doctor have prescribe anti hbs test and ultrasound after that do you think that i get anti hbs positive after 8 motnhs of tenfovir treatement and do i go with antiviral tenfovir please sugguest

[rohul]

thanks for answer i never drink in my life never smooke i am on  proper diet no oil diet and using entecavir then tenfovir but my sgpt was never normal not even on entecavir but when these tenfovir started my liver enzyme go for than 100 means 132 alt but i am very helath conscious i am confuse about my treatment as you know the dna viral load was 461 before entecavir and 47 before tenfovir but still my fibrosis increase f1 to f4 i am confuse about my results is tenfovir good to go on
anti hbe negative
hbe negative
and all other negative my endoscopy shows nothing

[Nmarius]

Stay positive! It s important! Wait for further results. Maybe some results are not correct, depends who read your liver biopsy. Anyway, how was your lifestyle in last 2 years? Did you drunk? Smoke? Other blood results?

[rohul]

thanks my fibroscan on 17 may 2016 show 10.8 kpa and on 31 may 2016 it shows 11.8 kpa
i had two liver biopsy
2014 it show fibrosis score1
2016 after 22 months fibrosis score 4
then i am on tenfovir and being on entecavir for 14 moths
i am on tenfovir from last 8 months and my dna becomes <20 in march 2016 but i am confused all about results please help me out please give advices

[Nmarius]

Post all your fibroscan results, and take antistr advices. Good luck.

[antistr]

fibroscan 11.9 is high, it correlates with your last biopsy. maybe first biopsy was inaccurate. anyway in my opinion the things you must do is first continue your medication, it is very important. you must also have a very strict diet, lose weight if you are overweight, (no alcohol,no smoking, limit saturated fats strictly, take a a lot of fresh fruits, vegetables and antioxidant supplements, you can find a lot of information about these at the old posts) and take vit d3 supplement as 10000 IU  per day. take fibroscan at 3-6 months interval and i am sure it will go down very quickly.

[rohul]

yes i am surprise by watching my report how can f1 to f4 when i am on entecavir and then tenefovir do you think that these antiviral make my liver fibrosis score to f4 please sugguest why should i continue with tenefovir my last fibroscan was 11.9 kpa please help me out

[rohul]

yes i am surprise by watching my report how can f1 to f4 when i am on entecavir and then tenefovir do you think that these antiviral make my liver fibrosis score to f4 please sugguest why should i continue with tenefovir my last fibroscan was 11.9 kpa please help me out

[antistr]

this results are not looking consistent. I advise you to take a fibroscan now and every three - six months, despite your high alt value it will a better way to follow up your liver state periodically.

[Nmarius]

you mean from f1 to f4?

[Nmarius]

Hi,
This is our goal, to get anti hbs, but is hard to receive on antivirals. Wait for your results, than share it. I think you should continue with your tnv, maybe it will reverse your fibrose score. Good luck!

[rohul]

thanks but i am suprise to see that fibrosis score has increased from 1 to 4 even my antiviral entecavir and then tenefovir . i used no oil and also no fast food still this fibrosis extension please help me on this