rescue drug for truvada

[neodyme]

If resistance occur to Truvada (in the long run), would Entecavir be the rescue drug, alone or in combo and which one ?

[cajim]

The general principle of the recommendations is to add a second drug that is not cross-resistant with the first (eg, adding a nucleotide drug such as adefovir or tenofovir when resistance to a nucleoside agent such as lamivudine, telbivudine, or entecavir is detected. The opposite concept applies to the patient with adefovir resistance (ie, add a nucleoside agent).

Because Truvada is a combo of emtricitabine and tenofovir, I guess you are right that Entecavir would be the rescue drug, but am not sure.