The general principle of the recommendations is to add a second drug that is not cross-resistant with the first (eg, adding a nucleotide drug such as adefovir or tenofovir when resistance to a nucleoside agent such as lamivudine, telbivudine, or entecavir is detected. The opposite concept applies to the patient with adefovir resistance (ie, add a nucleoside agent).
Because Truvada is a combo of emtricitabine and tenofovir, I guess you are right that Entecavir would be the rescue drug, but am not sure.
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