First I've ever heard that immune system damages the liver. The liver is damaged when the virus takes over the liver cell machinery to replicate itself. When it's done using the cell, it bursts out, rupturing the cell, and causing it's death.
Perhaps the poster was referring to autoimmune hepatitis.
search the forum there are links to the explanation of how immune system clears the virus, there is a lot of killing of infected cells on acute hepatitis with alt reaching also 3000-4000, this is the only way to clear the virus on immune system that works
when you are in the immune tollerant phase immune system cannot see infected cells so there is no killing and no damage at all, so in this phase you have extremely high hbvdna and normal alt/ast and no damage to the liver
if you search the forum there are links on studies about immune tollerant phase, then the second phase is immune clearance, in this phase you have alt elevations and liver damage, after immune clearance you can have inactive state with hbvdna und and normal alt or immune escape, usually precore eminus hbv, the virus mutates and you have continuous hbvdna detectable/alt ubnormal, liver damage
during immune clearance it is better to start therapy immediately since you can have more chances to clear the virus before it can mutate or go in to inactive phase, interferon alone or in combo with nucs is the best choice especially if you have low hbsag
Thanks Stefano! I definitely need to know more about the HBV phases. I believe I am in the immune clearance (low DNA, normal ALT) with little liver damage, or maybe the start of the escape phase. I will this out.
Copyright 1994-2016 MedHelp International. All rights reserved.
MedHelp is a division of Aptus Health.
This site complies with the HONcode standard for trustworthy health information.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.