vit d3 82ng/ml and lowering alt, not on therapy

[stef2011]

my sister just got tests results and the patern of hbvdna, alt looks inversely correlated with vitd 25oh>80ng/ml, this can be confirmed by time, she now has for the first time alt 40, hbvdna stable at around 200.000iu/ml, no liver damage 4.5kpa, hbsag around 18.000iu/ml

probably vitamin d is able to protect liver despite hbvdna detactable keeping alt 40, she will be checking fibroscan and hbsag next month

she has normal calcium as usual and creatinine and check every 3 months with vit d.she has daily vit d3 5000-8000iu

[4est]

some other sites say that 3000 - 5000 UI is OK - http://www.vitamindcouncil.org/about-vitamin-d/how-to-get-your-vitamin-d/vitamin-d-supplementation/

on the vitamin D the recomandation are not clear yet.

[stef2011]

no vit d dose can dmaage liver until 20000iu daily with normal calcium, just look at trials on people with hbv or hcv or liver diaseases

there are tons of disinformation with no human trials or study to prove vitamin d can have any toxicity while we do have studies that show antiviral effect and protection of liver and regression of liver damage by vit d.so obviously it cannot be toxic but the contrary

the levels must be 60-100ng/ml with normal calcium

[stef2011]

vitamin a is bad for hbv and not necessary, only d is necessary.betacarotene is a precursor of vit a, this is not toxic at any dose but again not nedded on hbv

C and E may help recover liver damage  and oxidative stress but no immune system/antiviral effect like vit D

i could not find that study that measured also high titers of hdl like 60-90mg/dl which are not common.anyway even older studies linked high hbvdna with low hdl

[grmr]

does this mean even 5000iu/daily can harm the liver??

[4est]

http://www.iom.edu/Reports/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D.aspx - new guidelines for vitamin D by IOM

[4est]

folowing link is related to HCV but also with vit D and interferon (look for What about vitamin D ? section)

http://hepatitiscnewdrugs.blogspot.com/2012/01/hepatitis-c-and-liver-health-getting-it.html

- what i don't understand is the "opposite" opinion:
1. Mega-vitamin supplements, particularly if they contain vitamins A and D, may be harmful. Excess vitamin A is very toxic to the liver.

2. The Bottom Line: Vitamin D3 may have a significant impact on HCV and treatment for it.

or maybe is just about the quantity of D supplements.

on the other hand (regarding other vitamin) they say:
"Based on the conducted randomised clinical trials, convincing evidence that beta-carotene, vitamin A, vitamin C, and vitamin E or their combinations are beneficial for treatment of alcoholic, autoimmune, hepatitis B or hepatitis C virus liver diseases, or liver cirrhosis could not be found."