baseline vitamin d around 10ng/ml 1 year ago
previous ast/alt around 60-70
previous hbvdna around 200.000iu/ml
previous hbsag around 18.000-19.000iu/ml
serum calcium stable low before and after vit d suplements 8.9mg/dl
results of my sister from baseline vit d deficency and low supplements 1000iu daily until march 2011 when she started vit d3 with 5000-10000iu daily.feeling very good and never tired since vit d equal or superior 70ng/ml
DATE therapy hbsag DNA ALT AST VIT D
15/02/2012 17476 43220 23 31 69 (5000iu daily)
20/12/2011 194000 40 38 82 (always 10.000iu daily)
28/09/2011 18183 88864 49 34 66 (5000iu daily)
26/07/2011 55 41 53 (5000iu daily)
16/06/2011 69 54 74 (5000iu daily)
15/04/2011 66 44
22/03/2011 16547>17milion 30 20 33 (1000iu daily) superinfection of unknown virus to stomach
08/02/2011 13661 9532000 72 50 21 (sumer sun) superinfection of unknown virus to stomach
15/06/2010 17379 221250 61 42 11 no vit d supplements - baseline values and stable like this in 2009 and 2008
hbsag and hbvdna iu/ml, vit d25oh ng/ml
fibroscan 2010 4.5kpa,
fibroscan early 2011 increased when hbvdna to milions to 6.1kpa
fibroscan today 5.1kpa
Vit D3 - 56.8 ng/ml ( 2 months back - 40.30 ng/m)
HBV DNA - 6450 IU/mL ( 6 months back - 10170 IU/mL)
HBsAg - 22378 IU/mL ( 6 months back - 16426 IU/mL)
AST - 27.0 (2 months back - 28.0)
ALT - 38.0 (2 months back - 31
S. Bilirubin Total - 1.0 ( 2 months back - 0.61)
bilirubin has nothing to do with vit d, it is just liver mulfunction due to hbv, vit d can only protect liver from damage and liver mulfunction
if bilirubin gets high it is best to make hbvdn und as soon as possible and check liver damage by fibroscan, keeping inmind other diseases can rise bilirubin and are of no relevance to liver damage or hbv
in last period i read some article about vit D and most of the articles agree that vit D reduce the inflamation and have some immunosuppressive effect.
( http://mpkb.org/home/pathogenesis/vitamind )
what i don't understand is the antiviral effect and the combination vit D + interferon because lowering the inflammation and being immunosuppressive is the oposite for antiviral or interferon (I miss something on this pictures)
many of this research just observe without clear explanation of all vit d pathways:
we know vitamin d has effect on macrophages but macrophages have many different populations that guide all immune response, inflammation and suppression of immune response, so you have to check wht is the status when you increase vitamin d:
if you have autoimmune disease, you increase vit d which activates the type of macrophages that act on suppressing immune response
if you have excess of cytokines and inflammation, for example what we have on active hbv you lower inflammation but at the same time increase immune sresponse
do vit d can do both lower immune response and increase immune response according to what is needed and this can take place even at the same time
in cases in which the immune response has been suppressed by supplementation with an immunosuppressant such as the secosteroid 25-D, one would expect to see fewer clinical manifestations of disease in the short-term, yet more advanced disease in the long-term. At a certain point,
depending on the clinical symptom or physiological markers of
disease, patients supplementing with vitamin D would be expected to
approach a "crossover point" when additional reduction of the
immune response is eclipsed by the advancing disease (Figure 2).
This outcome has been demonstrated in longitudinal studies, with
studies on sicker or older patients taking less time to realize the
Prevailing theories of vitamin D are imprecise and suggest
contradictory understandings of vitamin D metabolism.
• 25-hydroxyvitamin D is immunosuppressive.
• Supplementation of the secosteroid vitamin D temporarily
alleviates signs and symptoms of chronic disease but leads to a
long-term increase in morbidity.
• Molecular biology suggests that low levels of 25-D are a result
rather than a cause of the autoimmune disease process.
• A microbiota of bacterial pathogens may survive in the human body
by secreting proteins that antagonize the VDR and disable the
innate immune response.
• Elevated levels of 1,25-D exist at the site of disease and are an
indication that the innate immune system is responding to an
Yes I have read about the 2 schools of thought regarding vitamin d for chronic illness. One believes in the benefit of high level 25-OH-vit D, while the other cautions against that. It is suggested that people with low 25-OH-vit D levels to be tested for 1,25-OH-vit D to see if it's high, which indicates immune dysfunction caused by bacterial infection--a culprit some people believe is for a lot of chronic illnesses.
I haven't read enough to see which one is more believable. But the majority of doctors in my area seem to go with the first school of thought, because they only test 25-OH-vit D and recommend supplement when the level is low. I am a bit lost. Maybe I'll ask my doctor about 1,25-OH-vit D test?
those scholl of thoughts are all wrong, vitamin d doesn nothing but boost macrophages functionc, according to the needs of our body macrophages do the immune response or suppress it.our immune response are done of 2 parts at the same time one active and one to suppress, otherwise the active one would kill us
your thinking or those scholls are foolish, macrophages are the ones to destroy a liver a make cirrhosis, at the same time are the ones to repair liver and regress cirrhosis, so if you follow that way of thought my liver would be destroyed now and not normal after cirrhosis since i have my vit d normal levels
the point is not vitamin d, the point is balance in your immune systems and vitamin d does that balance according to what is needed to achieve that balance.
as regards hbv and hcv the must for all hbvers is take vitamin d and make your levels normal and if you have asma and autoimmune diseases it will heal them too all at the same time
i used the wrong word, it is not clear hbv, hcv or asma, the word i meant is it makes balance whtever the diseases and even at the same time.
this is simply because it acts on the many types of macrophages which are resident and different in al organs and then even within the organ there are many populations too, vit d will help balance all these populations in different organs
here s one of the latest findings on vt d action and pathways
Vitamin D: the alternative hypothesis.
Autoimmun Rev. 2009 Jul;8(8):639-44. Epub 2009 Feb 12.
Albert PJ, Proal AD, Marshall TG.
Weill Cornell Medical College, New York, NY 10065, USA. ***@****
Early studies on vitamin D showed promise that various forms of the “vitamin” may be protective against chronic disease, yet systematic reviews and longer-term studies have failed to confirm these findings. A number of studies have suggested that patients with autoimmune diagnoses are deficient in 25-hydroxyvitamin D (25-D) and that consuming greater quantities of vitamin D, which further elevates 25 D levels, alleviates autoimmune disease symptoms. Some years ago, molecular biology identified 25 D as a secosteroid. Secosteroids would typically be expected to depress inflammation, which is in line with the reports of symptomatic improvement. The simplistic first-order mass-action model used to guide the early vitamin studies is now giving way to a more complex description of action. When active, the Vitamin D nuclear receptor (VDR) affects transcription of at least 913 genes and impacts processes ranging from calcium metabolism to expression of key antimicrobial peptides. Additionally, recent research on the Human Microbiome shows that bacteria are far more pervasive than previously thought, increasing the possibility that autoimmune disease is bacterial in origin. Emerging molecular evidence suggests that symptomatic improvements among those administered vitamin D is the result of 25-D’s ability to temper bacterial-induced inflammation by slowing VDR activity. While this results in short-term palliation, persistent pathogens that may influence disease progression, proliferate over the long-term.
4 month ago (Nov) I had the first test for vit. D and the result was 17.6 and I start to take some vitamin D. Plan was to have 5000 UI/day but i was not paing so much atention and I was take 5000 UI/day frome time to time. now I made some other tests and the result were realy good and it can be related to this vit D, or can be just a coincidence.
- Vit D3 - 40,8 ug/l was 17,6 ug/l in Nov 2011 - (I was take 5000 UI
daily, in fact 2/week because some days I forgot to have it)
- HVB DNA - 34 IU.ml (was 97 IU/ml in May 2011 and 117 IU/ml in Nov)
- qHBsAg - 7845.14 was 8654,95 IU/ml in Nov 2011
- ALT - 19 (was 14 in May 2011, 18 in July 2011 and 20 in Nov )
- AST - 25 (was 21 in May 2011 and 22 in July 2011 and 23 in Nov )
- Cholesterol total - 148 very good (was 170 in May 2011, 136 in July
2011 and 153 in Nov)
- HDL - 35 (was 36 in Nov) - I was take some fish oil, but no effect
- LDL - 94 - (was 104 in Nov)
- Serum Iron - 118 (was 176 in July 2011 and 157 in Nov)
In the last 4 month the only supplemental that I was taken was vit D 5000 UI and some omega 3 (both from time to time) and increase some sport activity. I know that this is only one result and can be a coincidence or can be from some other causes.
indeed good results and 3 memebers have already achieved improvments increasing serum vit d
to all: remember to check calcium too especially when levels get to 60-90ng/ml and to drink 2 liters of water per day.
i check calcium monthly and with vitd25oh 71ng/ml and daily d3 10.000iu i got calcium increase from 9.8-10.1 to 10.4 (normal until 10.6) and no damage until 15
calcium increase is good because also caclium is connected with immune system but it must stay within normal ranges so better check it monthly when vit d is at 60-90ng/ml.
few days later calcium returned to 9.8 so may be just increased caclium absorption from food rich in calcium
I just read that grmr his on tdf+intf - good luck on this :)
Is possible that vit D is related to a lower side in INF, if I remember correct grmr have been on INF couple of years back and he can made a compassion (I think that we can made a supposition that couple of time ago he was with a lower value of vit D then now)
also consider latest study i linked about trl 7 activation by vit d and that changes of around 1000iu/ml hbvdna have very little if no meaning it is better to consider logs but yours is so low so dont worry about hbvdna
i also remember another study where intf good response increased also vit d so maybe the fact you get 113ng/ml by about 5000iu vit d3 daily is a sign your immune system or condition is improving.for me the minimum dose is still 10.000iu daily otherwise i get levels less than 60ng/ml
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